MVMR

Installation

MVMR can be installed from the MRCIEU R-Universe with

install.packages("MVMR", repos = c("https://mrcieu.r-universe.dev", "https://cloud.r-project.org"))

To install MVMR directly from the GitHub repository, first make sure you have the remotes package installed:

install.packages("remotes")

Then the MVMR package can be installed using:

library(remotes)
install_github("WSpiller/MVMR", build_opts = c("--no-resave-data", "--no-manual"), build_vignettes = TRUE)

To update the package just run the remotes::install_github("WSpiller/MVMR", build_opts = c("--no-resave-data", "--no-manual"), build_vignettes = TRUE) command again.

Description

We have written the MVMR R package to perform multivariable Mendelian randomization analyses, including heterogeneity statistics for assessing instrument strength and validity. The package accommodates any number of exposures greater than 1, and is currently includes a range of functions for estimating causal effects, as well as assessing conditional instrument strength and pleiotropic bias. For a detailed description regarding each function, please install the package and input vignette("MVMR")

Citation

The corresponding paper has been published in Statistics in Medicine, and can be accessed at:

Testing and correcting for weak and pleiotropic instruments in two-sample multivariable Mendelian randomization. Statistics in Medicine, 2021. [Internet]. 2021;sim.9133.

License

This project is licensed under GNU GPL v3.