Work on scRNAseq

[CathyXD]

Hi, team
I wondering how does this tool work on scRNAseq? Does it require pseudo-bulk? If so, what metadata is recommended to be used as pseudo group? If not, how to interpret sample heterogeneity with cell level ITH returned by DEPTH? Appreciate your response.

Regards
Cathy

[WangX-Lab]

Thanks for the excellent question. DEPTH was originally designed for analyzing bulk data. Yes, pseudo-bulk is required if analyzing scRNA-Seq data. In analyzing scRNA-Seq data, metadata should be individual patients. Best, Xiaosheng 发件人: ***@***.*** ***@***.***> 代表 Cathyyy0_0 发送时间: Monday, May 15, 2023 11:07 AM 收件人: WangX-Lab/DEPTH ***@***.***> 抄送: Subscribed ***@***.***> 主题: [WangX-Lab/DEPTH] Work on scRNAseq (Issue #2) Hi, team I wondering how does this tool work on scRNAseq? Does it require pseudo-bulk? If so, what metadata is recommended to be used as pseudo group? If not, how to interpret sample heterogeneity with cell level ITH returned by DEPTH? Appreciate your response. Regards Cathy — Reply to this email directly, view it on GitHub <#2> , or unsubscribe <https://github.com/notifications/unsubscribe-auth/ANDDKVFHNJYH7CJWN5QQKP3XGGMWFANCNFSM6AAAAAAYBSPLKQ> . You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>