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A benchmark suite covering the major steps in short and long-read genome sequence analysis pipelines such as basecalling, sequence mapping, de-novo assembly, variant calling and polishing.


  • Latest source code
git clone --recursive
  • Input datasets


  • RHEL/Fedora system prerequisites
sudo yum -y install $(cat rhel.prerequisites)
  • Debian system prerequisites
sudo apt-get install $(cat debian.prerequisites)

Python setup (optional: only needed for GPU benchmarks)

To run Python-based benchmarks nn-base, nn-variant and abea, follow the steps below:

  • Download and install miniconda from this link.

  • Follow the steps below to set up a conda environment:

# make sure channels are added in conda
conda config --add channels defaults
conda config --add channels bioconda
conda config --add channels conda-forge

# create conda environment named "genomicsbench"
conda create -n genomicsbench -c bioconda clair python==3.6.8
conda activate genomicsbench
conda install deepdish

pip install --upgrade pip
pip install -r requirements.txt
pypy3 -m ensurepip
pypy3 -m pip install --no-cache-dir intervaltree==3.0.2


  • CPU benchmarks
    • MKLROOT and MKL_IOMPS_DIR variables need to be set in Makefile to run grm. If you don't want to run grm, please comment grm related commands in Makefile
    • VTUNE_HOME variable needs to be set if you want to run any VTune based analyses
make -j<num_threads>
  • GPU benchmarks
    • Set CUDA_LIB=/usr/local/cuda or to the path of the local CUDA installation in Makefile.
    • Also ensure environment variables PATH and LD_LIBRARY_PATH include the path to CUDA binaries and libraries.
make -j<num_threads> gpu


  • CPU benchmarks
cd scripts
chmod +x ./
./ <path to input dataset folder> <input size to run: small | large>
  • GPU benchmarks
cd scripts
chmod +x ./
./ <path to input dataset folder> <input size to run: small | large>


If you use GenomicsBench or find GenomicsBench useful, please cite this work:

Arun Subramaniyan, Yufeng Gu, Timothy Dunn, Somnath Paul, Md. Vasimuddin, Sanchit Misra, David Blaauw, Satish Narayanasamy, Reetuparna Das. GenomicsBench: A Benchmark Suite for Genomics, In IEEE International Symposium on Performance Analysis of Systems and Software (ISPASS), 2021 (to appear)

    title={GenomicsBench: A Benchmark Suite for Genomics}},
    author={Subramaniyan, Arun and Gu, Yufeng and Dunn, Timothy and Paul, Somnath and Vasimuddin, Md. and Misra, Sanchit and Blaauw, David and Narayanasamy, Satish and Das, Reetuparna},
    booktitle={Proceedings of the IEEE International Symposium on Performance Analysis of Systems and Software (ISPASS)},

Issues and bug reporting

GenomicsBench is under active development and we appreciate any feedback and suggestions from the community. Feel free to raise an issue or submit a pull request on Github. For assistance in using GenomicsBench, please contact: Arun Subramaniyan (, Yufeng Gu (, Timothy Dunn (


Each benchmark is individually licensed according to the tool it is extracted from.


This work was supported in part by Precision Health at the University of Michigan, by the Kahn foundation, by the NSF under the CAREER-1652294 award and the Applications Driving Architectures (ADA) Research Center, a JUMP Center co-sponsored by SRC and DARPA.