Add variant region condition for dups ending in UTR

src/hgvs/utils/altseqbuilder.py

@@ -181,7 +181,13 @@ def _get_variant_region(self):
         :rtype str
         """
         if (
-            self._var_c.posedit.pos.start.datum == Datum.CDS_END
+            self._var_c.posedit.edit.type in ["ins", "sub"]
+            and self._var_c.posedit.pos.start.datum == Datum.CDS_END
+            and self._var_c.posedit.pos.end.datum == Datum.CDS_END
+        ):
+            result = self.T_UTR
+        elif (
+            self._var_c.posedit.edit.type == "dup"
             and self._var_c.posedit.pos.end.datum == Datum.CDS_END
         ):
             result = self.T_UTR

tests/test_hgvs_variantmapper.py

@@ -118,6 +118,12 @@ def test_map_of_c_out_of_reference_bound(self):
         with pytest.raises(HGVSError, match="coordinate is out of bounds"):
             self.vm.c_to_p(var_c)
 
+    def test_map_of_dup_three_prime_utr(self):
+        hgvs_c = "NM_153223.3:c.2959_*1dup"
+        var_c = self.hp.parse_hgvs_variant(hgvs_c)
+        var_p = self.vm.c_to_p(var_c)
+        self.assertEqual(str(var_p), "NP_694955.2:p.?")
+
 
 if __name__ == "__main__":
     unittest.main()

tests/test_hgvs_variantmapper_cp_sanity.py

@@ -164,6 +164,11 @@ def test_three_prime_utr(self):
         hgvsp_expected = "MOCK:p.?"
         self._run_conversion(hgvsc, hgvsp_expected)
 
+    def test_dup_three_prime_utr(self):
+        hgvsc = "NM_999999.1:c.12_*1dup"
+        hgvsp_expected = "MOCK:p.?"
+        self._run_conversion(hgvsc, hgvsp_expected)
+
     def test_deletion_into_three_prime_utr_frameshift(self):
         hgvsc = "NM_999999.1:c.27_*3del"
         hgvsp_expected = "MOCK:p.(Lys9XaafsTer?)"