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ENTRY EC 1.14.18.1
NAME Monophenol monooxygenase
Tyrosinase
Phenolase
Monophenol oxidase
Cresolase
SYSNAME Monophenol,L-dopa:oxygen oxidoreductase
CLASS Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With another compound as one donor, and incorporation of one atom
of oxygen
REACTION L-Tyrosine + L-Dopa + O2 = L-Dopa + Dopaquinone + H2O
SUBSTRATE L-Tyrosine
L-Dopa
Benzenediol
O2
PRODUCT L-Dopa
Dopaquinone
H2O
COFACTOR Copper
COMMENT A group of copper proteins that also catalyse the reaction of
EC 1.10.3.1, if only benzenediols are available as substrate.
(EC 1.10.3.1 Catechol oxidase)
PATHWAY PATH: MAP00350 Tyrosine metabolism
PATH: MAP00740 Riboflavin metabolism
PATH: MAP00940 Flavonoids, stilbene and lignin biosynthesis
PATH: MAP00950 Alkaloid biosynthesis I
GENES DME: CG5779
MMU: 94856 98880(Tyr)
HSA: 7299(TYR)
DISEASE MIM: 203100 Tyrosinase
DBLINKS IUBMB Enzyme Nomenclature: 1.14.18.1
ExPASy - ENZYME nomenclature database: 1.14.18.1
WIT (What Is There) Metabolic Reconstruction: 1.14.18.1
BRENDA, the Enzyme Database: 1.14.18.1
///
ENTRY EC 3.4.21.50
NAME Lysyl endopeptidase
Achromobacter proteinase I
Endoproteinase Lys-C
Ps-1
CLASS Hydrolases
Acting on peptide bonds (peptidases)
Serine endopeptidases
REACTION Preferential cleavage: Lys+, including -Lys-|-Pro-
SUBSTRATE Protein
Peptide
H2O
PRODUCT Protein
Peptide
COMMENT A chymotrypsin homologue isolated from Achromobacter lyticus.
Enzymes with similar specificity are produced by Lysobacter
enzymogenes (Endoproteinase Lys-C) and Pseudomonas aeruginosa
(Ps-1).
COMMENT Also hydrolyses lysine amides and esters.
GENES MJA: MJ1468
MTH: MTH995
STRUCTURES PDB: 1ARC 1ARB
DBLINKS IUBMB Enzyme Nomenclature: 3.4.21.50
ExPASy - ENZYME nomenclature database: 3.4.21.50
WIT (What Is There) Metabolic Reconstruction: 3.4.21.50
BRENDA, the Enzyme Database: 3.4.21.50
SCOP (Structural Classification of Proteins): 3.4.21.50
///