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<link href="help.css" | ||
type=text/css rel=stylesheet> | ||
<h2>Example - Performing a Meta-Analysis</a></h2> | ||
<p>This section presents an example of performing a meta-analysis using Open Meta-Analyst.</p> | ||
<h3><a name="open_data">Opening the Data Set</h3> | ||
To run the example, first open the | ||
example data set: | ||
<ol> | ||
<li>Select <b>open</b> from the <b>File</b> menu.</li> | ||
<li>Select the fiile BCG.oma.</li> | ||
<li>Click <b>Open</b>.</li> | ||
</ol> | ||
<p>Open Meta-Analyst displays the data shown below.</p> | ||
<img src="images/BCG.png"></img> | ||
<h3><a name="run_analysis">Running the Analysis</a></h3> | ||
<p>To perform a meta-analysis on the data, select <b>meta-analysis</b> from the | ||
<b>Analysis</b> menu. This opens the Methods & Parameters dialog, as shown | ||
below.</p><img src="images/analysis_parameters_dialog.png"></img> | ||
<p>You can select a method for the analysis in the analysis method field. The default method | ||
is Binary Random, which uses the DerSimonian-Laird method to fit a random-effects model. The other options in the dialog are | ||
described in | ||
<a href="#analysis_options">Analysis Options</a>. </p> | ||
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<p>Click <b>OK</b> to | ||
perform the analysis. The results are displayed in the results/analysis window.</p> | ||
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<h3><a name="summary">Viewing the Results</a></h3> | ||
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<p>The results of the meta-analyis consist of two parts:</p> | ||
<ul> | ||
<li>A Summary, which displays the overall numerical results of the meta-analysis.</li> | ||
<li>A forest plot of the point estimates for each study and the overall results.</li> | ||
</ul> | ||
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||
<img | ||
src="images/ma_standard_summary.png"></img> | ||
<img | ||
src="images/ma_standard_forest_small.png"></img> </img> | ||
<p>In the example above, the meta-analysis calculations are performed in logarithmic scale, so the model results | ||
are displayed in standard and log scale. When calculations are performed in standary scale - for example, when the metric is risk difference - only one table is displayed. | ||
</p> | ||
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<p>The forest plot shows the effect sizes and confidence intervals for each individual study, as well as the overall results. | ||
The plot also displays the raw data for the studies and the overall results in three columns:</p> | ||
<ul> | ||
<li>ES(LL, UL) - Effect size (lower limit, upper limit)</li> | ||
<li>Ev/Trt - Events in the treated group / Total number in the treated group</li> | ||
<li>Ev/Ctrl - Events in the control group / Total number in the control group</li> | ||
</ul> | ||
<h3><a name="specify_metric">Changing the Metric for the Effect Size</a></h3> | ||
<p> By default, the metric for the effect size is set to odds ratio (OR). To change | ||
the metric: | ||
<ol> | ||
<li>Select <b>metric</b> in the <b>Analysis</b> menu.</li> | ||
<li>Select <b>two-arm</b>. </li> | ||
<li>Select a metric from the pop-up | ||
menu, as shown below.</p><img | ||
src="images/select_metric.png"></img> | ||
<p><b>Note:</b> If you select <b>one-arm</b>, only the first two data columns (Tx An and Tx AN) | ||
are included in the analysis. The Tx Bn and Tx BN columns are shaded grey. | ||
<p>When you select a metric, the effect | ||
sizes and confidence intervals are immediately updated. </p> |
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<link href="help.css" | ||
type=text/css rel=stylesheet> | ||
<h2>Creating a New Data Set</a></h2> | ||
<p>To create a new data set:</p> | ||
<ol> | ||
<li>Type the name of the data set:</li> | ||
<img src="images/dataset_name.png"></img> | ||
</li> | ||
<li>Select the type of data you are working with. In this example, the data type is binary.</li> | ||
<img src="images/dataset_type.jpg"</img> | ||
</li> | ||
<li> Select <b>create new</b>. | ||
<p>This opens the dialog shown below.</p><img | ||
src="images/outcome_dialog.png"> | ||
<li>In the dialog, type a name for the outcome of the test, and select the | ||
type of outcome, <b>Binary</b> or <b>Continuous</b>, depending on the type of | ||
data you are analyzing. Then click <b>OK</b>.</li> | ||
</ol> | ||
<p>The Open Meta-Analyst window now displays a row of fields where you can | ||
enter data. For binary data, the row appears as shown | ||
below.</p><img | ||
src="images/added_binary_fields.png"></img> |
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