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jjgao committed Nov 22, 2019
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# [Introduction](introduction)
From release 2.2 cBioportal supports multiple reference genomes. This means you can have the hg19 datasets coexist with the hg38 ones in the same portal database. It is also possible to reconfigure the existing cBioPortal instance so that human and mouse data can be imported to the same
portal instance and shown in the UI.
The document outlines the steps you need to follow to have cBioPortal support multiple reference genomes.
From release 3.1, cBioportal supports multiple reference genomes. This means the hg19 datasets can co-exist with the hg38 ones in the same portal database. We also support mouse genomes (mm10), but it is not recommended to have both human and mouse data in the same instance of the cBioPortal.

This document outlines the steps to support multiple reference genomes in your instance of cBioPortal.

# [How is it supposed to work?](workflow)
1. [Import Reference Genome](Import-reference-genome) into your cBioPortal database. If the version of your portal instance is lower than 2.2, you will have to [update your cBioPortal installation](Updating-your-cBioPortal-installation)
1. [Import Reference Genome](Import-reference-genome) into your cBioPortal database. If the version of your portal instance is lower than 3.1, you will have to [update your cBioPortal installation](Updating-your-cBioPortal-installation)
and migrate your database schema to the latest. The migrartion script by default will add three reference genomes (hg19, hg38, mm10) to the database.
2. [Update the reference genome gene database table](Updating-gene-and-gene_alias-tables) to include the genes from the reference genome of interest to the database. You will also need to update both gene and gene alias tables in order to support other species such as mouse.
3. [Import Cancer Study](#import-cancer-study) of a given reference genome into the portal database. You will need to add a new propertity of **reference genome** to your meta_study file. You must use **ucsc** and **ncbi** options
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