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Generalizability
Problem: Computational phenotype definitions may have limited generalizability because they are tailored to specific source vocabularies or hospital systems.
Solution: PhenKnowVec is built on the Observational Medical Outcomes Partnership (OMOP) common data model, which allows it to leverage mappings between source vocabularies (e.g. ICD9-CM, MEDRA, GPT) and standardized clinical terminologies (e.g. SNOMED, LOINC, RxNorm, CPT4).
Experiment: For each phenotype, we examined what information is gained and/or lost when deriving pediatric and adult patient cohorts using different the clinical code sets defined in Table 2. For all comparisons, the Source Vocabulary - Exact None
code set was be used as the gold standard.
The results from these experiments are organized by phenotype and listed below.