vignette improvement: referenced paper instead of including all results

cbg-ethz · Sep 7, 2018 · a715a02 · a715a02
1 parent dec3376
commit a715a02
Show file tree

Hide file tree

Showing 2 changed files with 81 additions and 367 deletions.
diff --git a/DESCRIPTION b/DESCRIPTION
@@ -1,7 +1,7 @@
 Package: mnem
 Type: Package
 Title: Mixture Nested Effects Models
-Version: 0.99.14
+Version: 0.99.15
 Author: Martin Pirkl
 Maintainer: Martin Pirkl <martin.pirkl@bsse.ethz.ch>
 Description: Mixture Nested Effects Models (mnem) is an extension of Nested Effects Models and allows for the analysis of single cell perturbation data provided by methods like Perturb-Seq (Dixit et al., 2016) or Crop-Seq (Datlinger et al., 2017). In those experiments each of many cells is perturbed by a knock-down of a specific gene, i.e. several cells are perturbed by a knock-down of gene A, several by a knock-down of gene B, ... and so forth. The observed read-out has to be multi-trait and in the case of the Perturb-/Crop-Seq gene are expression profiles for each cell. mnem uses a mixture model to simultaneously cluster the cell population into k clusters and and infer k networks causally linking the perturbed genes for each cluster. The mixture components are inferred via an expectation maximization algorithm.