This method is described in the publication from Biorxiv, 2018 available at https://www.biorxiv.org/content/10.1101/426593v2
ICTD web application demo is available at : https://shiny.ph.iu.edu/ICTD/
ICTD web application tutorial is available at : https://github.com/changwn/ICTD/blob/master/vignettes/ICTD_server_tutorial.md