Thank you for visiting this project page. Great, that you are interested to learn more about this research. This github repository is authored by Christian Paret and Malte Zopfs, Central Institute of Mental Health in Mannheim, Germany.
The modulation of brain circuits of emotion is a promising pathway to the treatment of Borderline Personality Disorder (BPD). Precise and scalable approaches have yet to be established. The research presented in this repository is from a study investigating neurofeedback (NF) as a means to improve brain self-regulation in BPD. A 10-session Amyg-EFP NF training in parallel to a 12-weeks residential Dialectical Behavior Therapy (DBT) program. N=15 patients with BPD completed the training, N=14 matched patients served as DBT-only controls.
This directory contains
- This readme file
- Two subdirectories:
- Directory "questionnaires_and_descriptives", including the code for data analysis of clinical self-report data a demographic/clinical descriptive information of participants and a readme-file. Follow information in the readme file to reproduce the analysis.
- Directory "trainingsession_analysis", including the code for data analysis. There is also a readme-file. Follow information in the readme file to reproduce the analysis
Results showed significant learning of Amyg-EFP modulation with NF training. No clinical benefits of NF beyond DBT-only were observed. Measured with scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Feasibility of Amyg-EFP NF as add-on to BPD treatment was shown. Clinical utility remains to be investigated. The project involved a second study, where simultaneous fMRI-EEG was acquired in N=16 subjects with BPD. Mapping of Amyg-EFP to whole-brain fMRI-BOLD signal was investigated. More information of this study can be found in the original article. Results from this study are available on neurovault (https://neurovault.org/collections/JBICXOQC/). Single-subject data can be requested from the author. Sharing of this data is subject to European and national data protection law.
Aggregated subject data is available from the original publication. Reasonable requests for individual subject data should be directed to christian.paret[at]zi-mannheim.de. Please introduce yourself and explain the purpose (scientific question and hypothesis) for that you need the data, and what kind of data is needed. Data can be shared in line with European and national data protection regulations.
Issues related to the code can be submitted via Github's Issues function. Please address your project-related questions to christian.paret[at]zi-mannheim.de. We are all busy people, but we will do our best to respond quickly.
Please cite the original article when you reference this repository in your work:
TBD