First, make sure you have Node.js, Typescript, and typings installed.
Next, run these commands:
$ git clone https://github.com/chuvpilo/nodejs-express-typescript-boilerplate
$ cd nodejs-express-typescript-boilerplate
$ npm install
$ typings install
Now, run the app:
$ node app.js
You will need to configure to complile Typescript to JavaScript either in your IDE, such as WebStorm, or using Grunt, which is nicely described in this post.
Enjoy! :)
-Gleb