v1.22.2

1.22.2 (2023-02-03)

⚠️ Reversion ⚠️

• Reverted the change in v1.22.1 to fluorouracil & capecitabine Therapeutic Recommendation text for Activity Score 1.5. The change was made in error and is being reverted to the version of the file in v1.22.0. See the November 2018 update on the fluoropyrimidines CPIC guideline page for more info

Bug Fixes

• fix frequency exporter to not show null allele data (79745ba)

v1.22.1

1.22.1 (2023-01-31)

Bug Fixes

• [fluorouracil & capecitabine] [RECOMMENDATION] Fixed the Therapeutic Recommendation text for Activity Score 1.5 to match the published guideline
• properly encode spaces in filenames uploaded to S3 (1394d80)

Updates

• [simvastatin-CYP3A4] PharmGKB level changed from none to 3
• [atorvastatin-CYP3A5] PharmGKB level changed from none to 3
• [atorvastatin-CYP3A4] PharmGKB level changed from none to 3
• [lovastatin-HMGCR] PharmGKB level changed from none to 3
• [rosuvastatin-CYP3A5] PharmGKB level changed from none to 3
• [lovastatin-CYP3A5] PharmGKB level changed from none to 3
• [simvastatin-CYP3A5] PharmGKB level changed from none to 4
• [tacrolimus-CYP3A4] PharmGKB level changed from 1B to 2A
• [fluvastatin-HMGCR] PharmGKB level changed from none to 3
• [fluvastatin-CYP3A4] PharmGKB level changed from none to 3
• [atorvastatin-HMGCR] PharmGKB level changed from none to 3
• [tolbutamide-G6PD] PGx testing level changed from none to Actionable PGx
• [mivacurium-BCHE] PGx testing level changed from none to Actionable PGx
• [trametinib-G6PD] PGx testing level changed from none to Informative PGx
• [tolazamide-G6PD] PGx testing level changed from none to Actionable PGx
• [capecitabine-DPYD] PGx testing level changed from Actionable PGx to Testing recommended

v1.22.0

1.22.0 (2023-01-27)

Features

• updated to PharmVar version 5.2.17 with an update to CYP4F2
• add new make script for copying the DB (e9ebb6a)

Bug Fixes

• data update (277ceef)

v1.21.6

1.21.6 (2022-12-21)

Bug Fixes

• data update (c4dcd9d)

v1.21.5

1.21.5 (2022-12-20)

Bug Fixes

• update data (2476a6c)

v1.21.4

1.21.4 (2022-12-20)

Bug Fixes

• update data (3d23c05)

v1.21.3

1.21.3 (2022-10-31)

Features

• updated to support PharmVar version 5.2.11

Bug Fixes

• remove unneeded data caching scripts (3cf620d)
• fix function assignment for G6PD allele function reference file

v1.21.2

1.21.2 (2022-10-24)

Bug Fixes

• fix population summary stats on frequency export sheets (d4c13f8)

v1.21.1

1.21.1 (2022-10-20)

Bug Fixes

• move B allele to top of G6PD allele function file so it becomes the inferred frequency
• change primaquine to use only one population
• normalize "general" population sheet name
• normalize "Malignant Hyperthermia" casing
• put CYP4F2 *3 mention in warfarin diagram
• do not generate diplotype/phenotype frequencies for x-linked genes (8f4a7d9)
• normalize user-generated function descriptions (ca8846d)
• put CYP4F2 *3 mention in warfarin diagram (d0f57d4)

v1.21.0

1.21.0 (2022-10-04)

Features

• update from PharmVar for CYP2C19
• new data for the just-published G6PD guideline
• add drug flowcharts for G6PD drugs (42c750f)

Bug Fixes

• add pointer to fosphenytoin flow chart (f395963)
• fix ordering bug for variants in PharmCAT export (795cafa)
• standardize activity values and scores to always use decimal format (4e458f4)