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Package: POINT | ||
Type: Package | ||
Title: Protein Structure Guided Local Test | ||
Version: 1.2 | ||
Date: 2022-06-05 | ||
Version: 1.3 | ||
Date: 2023-10-01 | ||
Author: Rachel Marceau West, Shannon T. Holloway | ||
Maintainer: Shannon T. Holloway <shannon.t.holloway@gmail.com> | ||
Description: Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>. | ||
License: GPL-2 | ||
Depends: methods, stats, rARPACK, Matrix, CompQuadForm | ||
NeedsCompilation: no | ||
Encoding: UTF-8 | ||
RoxygenNote: 6.1.1 | ||
RoxygenNote: 7.2.1 | ||
Collate: 'A_Kernel.R' 'A_BurdenKernel.R' 'A_LinearKernel.R' | ||
'A_PolyKernel.R' 'B_PvMethod.R' 'B_PvMethod_Davies.R' | ||
'B_PvMethod_Liu.R' 'C_BinomialTrait.R' 'C_GaussianTrait.R' | ||
'D_NullResult.R' 'calcLocalKernel.R' 'distanceMatrix.R' | ||
'mainCode.R' 'point.R' 'pvResamp.R' | ||
Packaged: 2022-06-05 18:59:46 UTC; 19194 | ||
Packaged: 2023-10-01 17:33:27 UTC; 19194 | ||
Repository: CRAN | ||
Date/Publication: 2022-06-06 23:10:27 UTC | ||
Date/Publication: 2023-10-01 18:00:02 UTC |
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POINT v1.3 (Release date: 2023-10-01) | ||
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Changes: | ||
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* Cleaned-up documentation; removed package.Rd file | ||
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POINT v1.2 (Release date: 2022-06-06) | ||
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Changes: | ||
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* Maintainer e-mail address |
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