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Update with eLife publication
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dhimmel committed Sep 22, 2017
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7 changes: 6 additions & 1 deletion README.md
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# Hetionet: an integrative network of disease

Hetionet is a hetnet — network with multiple node and edge (relationship) types — which encodes biology. The hetnet was designed for [Project Rephetio](http://thinklab.com/p/rephetio "Repurposing drugs on a hetnet · Project Rephetio on Thinklab"), which aims to systematically identify why drugs work and predict new therapies for drugs.
Hetionet is a hetnet — network with multiple node and edge (relationship) types — which encodes biology. The hetnet was designed for [Project Rephetio](https://doi.org/10.15363/thinklab.4 "Repurposing drugs on a hetnet · Project Rephetio on Thinklab"), which aims to systematically identify why drugs work and predict new therapies for drugs.
The research article describing Project Rephetio and Hetionet v1.0 is:

> [**Systematic integration of biomedical knowledge prioritizes drugs for repurposing**](https://doi.org/10.7554/eLife.26726)<br>
<small>Daniel S Himmelstein, Antoine Lizee, Christine Hessler, Leo Brueggeman, Sabrina L Chen, Dexter Hadley, Ari Green, Pouya Khankhanian, Sergio E Baranzini</small><br>
_eLife_ (2017-09-22) DOI: `10.7554/eLife.26726`

Version 1.0 contains 47,031 nodes of 11 types and 2,250,197 relationships of 24 types. This repository is currently only a download location for Hetionet. The data integration and hetnet creation occurs in a separate repository ([`dhimmel/integrate`](https://github.com/dhimmel/integrate/tree/d482033bcaa913a976faf4a6ee08497281c739c3)) and is imported to this repository by [`import.ipynb`](import.ipynb).

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Hetionet is a network of biology, disease, and pharmacology. Knowledge from millions of biomedical studies over the last half century have been encoded into a single hetnet. Version 1.0 contains 47,031 nodes of 11 types and 2,250,197 relationships of 24 types.

We created link:https://github.com/dhimmel/hetionet[Hetionet] v1.0 for link:https://doi.org/bszr[Project Rephetio] (link:https://doi.org/10.1101/087619[manuscript]) — where we systematically looked at why drugs work and predicted new uses for existing drugs.
We created link:https://github.com/dhimmel/hetionet[Hetionet] v1.0 for link:https://doi.org/bszr[Project Rephetio] (link:https://doi.org/10.7554/eLife.26726[publication]) — where we systematically looked at why drugs work and predicted new uses for existing drugs.

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2 changes: 1 addition & 1 deletion hetnet/neo4j/docker/guides/hetionet.html
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<p>Hetionet is a network of biology, disease, and pharmacology. Knowledge from millions of biomedical studies over the last half century have been encoded into a single hetnet. Version 1.0 contains 47,031 nodes of 11 types and 2,250,197 relationships of 24 types.</p>
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<p>We created <a href="https://github.com/dhimmel/hetionet">Hetionet</a> v1.0 for <a href="https://doi.org/bszr">Project Rephetio</a> (<a href="https://doi.org/10.1101/087619">manuscript</a>) — where we systematically looked at why drugs work and predicted new uses for existing drugs.</p>
<p>We created <a href="https://github.com/dhimmel/hetionet">Hetionet</a> v1.0 for <a href="https://doi.org/bszr">Project Rephetio</a> (<a href="https://doi.org/10.7554/eLife.26726">publication</a>) — where we systematically looked at why drugs work and predicted new uses for existing drugs.</p>
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