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Haplotype-based-membership-inferences

The source code to conduct haplotype-based membership inferences (KHF-inference, KHB-inference and NHF-inference).

Prerequisites

The vcf files and panel file from 1000 genomes project is used as the original data.

The haplotypes from the original data are obtained by the softerware Haploview

Getting started

  1. collect_haplotype: collect known haplotypes from 1000 genomes and select the target haplotypes.

  2. build_private_database: randomly extract a group of genomes to build a private database, save the frequency table and beacon table.

Performing membership inferences

KHF-inference: infer known haplotypes from the frequency table.

KHB-inference: infer known haplotypes from the beacon table.

NHF-inference: reconstruct novel (unknown) haplotypes from the frequency table.

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