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Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints

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This repository holds the code and data for the following manuscript:

Minikel EV, Zhao HT, Le J, O’Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O’Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Res. 2020 Aug 10; PMID: 32776089

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Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints

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