PANTHER:PTN000042666 PANTHER:PTN000042665

[ValWood]

from:
#1873

both referring to
https://www.pombase.org/gene/SPAC11E3.12

• SPAC11E3.12 mitochondrial thioredoxin family protein mitochondrial electron
  transport, NADH to ubiquinone GO_Central Schizosaccharomyces pombe IBA PANTHER:PTN000042666 PAINT_REF:10371

• SPAC11E3.12 mitochondrial thioredoxin family protein respiratory electron transport chain GO_Central Schizosaccharomyces pombe IBA PANTHER:PTN000042665 PAINT_REF:10371 20170427

• SPAC11E3.12 mitochondrial thioredoxin family protein NADH dehydrogenase (ubiquinone) activity GO_Central Schizosaccharomyces pombe IBA PANTHER:PTN000042665 PAINT_REF:10371 20170427

(we discussed in detail this week about the other protein which is a member of the NADH complex in fungi)

[ValWood]

See
#31
for some history

[thomaspd]

@marcfeuermann can you please look into the annotations for PTHR10371. Specifically, it sounds like Val is suggesting that there should be a loss of these functions for the pombe ortholog, as it lacks a mitochondrial electron transport I system (@ValWood is that correct?)

[ValWood]

Yes that's correct. Essentially complex I in metazoa is a large >44 subunit complex. It is clearly multifunctional, but it is not well studied. It does have NADH dehydrogenase activity. In yeast (at least pombe and cerevisiae, but not all yeast) this function is performed by a completely different protein.

however pombe has 3/>44 subunits (I think cerevisiae has 1, or 2). There is speculation that these have a role in iron sulphur cluster protein assembly or lipid metabolism, but essentially we don't know what they do. All we know is they aren't part of the electron transport chain.

[marcfeuermann]

It seems that this has already been corrected by Pascale on 2018-09-04.

[thomaspd]

Thanks, I will close this issue.

[ValWood]

I still see the annotations here, should I? Oct seems a long time ago?

[marcfeuermann]

I'm sorry, I can check PTHR10371 again and again, but the fact is that all propagations have been blocked for PTN000822143 by Pascale on 2018-09-04. The problem is not on the PAINT annotation side. May be @huaiyumi you might find why they did not disappear ?
Thanks
Marc.

[ValWood]

Thansk Marc, Assigned to @huaiyumi

[pgaudet]

SPAC11E3.12 has no more IBAs