IPR008011 -> respiratory chain complex I (sensu Eukarya)

[gocentral]

IPR008011 -> maps to respiratory chain complex I (sensu
Eukarya)
and
oxidoreductase activity, acting on NADH or NADPH
and

also IPR002023 both of these domains
maps to
NADH dehydrogenase activity
and
respiratory chain complex I (sensu Eukarya)

My summer student Lynda Groocock has pointed out that
this complex is a ~30-40 subunit complex.
But these 2 subunits are the only 2 which are present
in S. pombe, and only IPR008011 is present in S.
cerevisiae which is reported not to have respiratory
chain complex i (as far as we know).

Therefore, we think that the associated mappings should
be refined or removed.
possibly also the swiss-prot entries should be updated.

Both appear to be an iron sulpher binding proteins.

considering the following from PMID: 1518044

“No function has been ascribed to many of the subunits,
but some of the sequences indicate the presence of
hitherto unsuspected biochemical functions. Most
notably the identification of an acyl carrier protein
in both the bovine and Neurospora crassa complexes
provides evidence that part of the complex may play a
role in fatty acid biosynthesis in the organelle,
possibly in the formation of cardiolipin

…perhaps these 2 subunits are part of a subcomplex
which has other functions?

…also the deletion of IPR008011 containing protein in
S. cerevisiae is not viable rather than petite which
seems to suggest a function other than aaerobic
respiration in this yeast.

Reported by: ValWood

Original Ticket: geneontology/annotation-issues/31

[gocentral]

- milestone: —> InterPro

Original comment by: mah11

[gocentral]

- assigned_to: nobody —> orchard

Original comment by: mah11

[gocentral]

- status: open —> closed

Original comment by: orchard

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Hi Sandra,

What was the resolution of this one. My summer student is
completing her write up and we just wanted to check whether
you agree with the updated function of this one?

thanks

Val

Original comment by: ValWood