Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Do we need all terms under GO:0006271 DNA strand elongation involved in DNA replication'? #16484

Closed
pgaudet opened this issue Oct 8, 2018 · 2 comments
Assignees

Comments

@pgaudet
Copy link
Contributor

pgaudet commented Oct 8, 2018

No description provided.

@pgaudet pgaudet self-assigned this Oct 8, 2018
@mah11
Copy link
Collaborator

mah11 commented Oct 9, 2018

Leading and lagging strand elongation are profoundly different from each other, so these are essential (including the parts of lagging str. elong.):

GO:0006272 ! leading strand elongation
GO:0006273 ! lagging strand elongation
GO:0090629 ! lagging strand initiation
GO:0033567 ! DNA replication, Okazaki fragment processing
GO:0043137 ! DNA replication, removal of RNA primer

Bacterial replication uses fewer different polymerases, so it's probably worth keeping:

GO:1902331 ! DNA strand elongation involved in bacterial-type DNA replication
(which implies also keeping GO:1902319! DNA strand elongation involved in nuclear cell cycle DNA replication)

... and maybe add leading and lagging bacterial terms? Up to those who annotate bacteria, I think.

I don't know whether there are any differences in strand elongation between mitotic and premeiotic replication; in species that have both, there are differences in regulation of initiation but I'm not sure whether anything else differs, nor, if so, what. That means I can't make an explicit case for or against
differentiating between "mitotic" and "premeiotic" under "nuclear cell cycle DNA replication"; "nuclear cell cycle" may be precise enough.

@ValWood
Copy link
Contributor

ValWood commented Nov 6, 2020

closing

@ValWood ValWood closed this as completed Nov 6, 2020
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

3 participants