BP NTRs: 'effector-mediated modulation of host DNA synthesis by symbiont' and child term 'effector-mediated induction of host DNA synthesis'

[CuzickA]

Please provide as much information as you can:

• Suggested term label:
  'effector-mediated modulation of host DNA synthesis by symbiont'
  and child term
  'effector-mediated induction of host DNA synthesis'

• Definition (free text)
  NTR: effector-mediated modulation of host DNA synthesis by symbiont
  A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of DNA synthesis involved in DNA replication (GO:0090592). The host is defined as the larger of the organisms involved in a symbiotic interaction. PMID:25888589

AND child term NTR: effector-mediated induction of host DNA synthesis
A process mediated by a molecule secreted by a symbiont that results in the activation of DNA synthesis involved in DNA replication (GO:0090592). The host is defined as the larger of the organisms involved in a symbiotic interaction. PMID:25888589

• Reference, in format PMID:#######
  PMID:25888589

• Gene product name and ID to be annotated to this term

• UMAG_02239 See1 from Ustilago maydis

• Parent term(s)
  GO:0140418 effector-mediated modulation of host process by symbiont

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information
  New GO BP terms required for publication curation into PHI-base using our new community curation tool PHI-Canto in collaboration with @ValWood.

I also noticed a typo in GO:0140418 definition should be 'suppression' not 'suppresion' and also a typo in GO:0140590 'supression' should be 'suppression'. Thanks, Alayne.

[pgaudet]

@Antonialock @CuzickA

DNA synthesis seems to be the readout here - (GO:0071897 DNA biosynthetic process is 'The biosynthetic process resulting in the formation of DNA.' ) Both the paper you mention, and PMID:29314018 mention that the See1 effector "interacts with a maize homolog of SGT1 (Suppressor of G2 allele of skp1), a factor acting in cell cycle progression in yeast" (PMID:25888589) and "U. maydis See1 was identified as the first cell type-specific fungal effector, being required for induction of cell cycle reactivation in bundle sheath cells." (PMID:29314018)

So I propose to label the new term: "effector-mediated induction of cell cycle reactivation in host"
This would be part_of "GO:0051819 induction by symbiont of tumor or growth in host"

I dont think we need the general term 'effector-mediated modulation of host DNA synthesis by symbiont', until we have examples of inhibition.

Does that work for (and Alayne) ?

Thanks, Pascale

[ValWood]

Apologies, my fault I checked, but I didn't check the paper, only the ontology positioning. That sounds correct.

[CuzickA]

Sound good thanks.

Is it possible for the new term "effector-mediated induction of cell cycle reactivation in host" to also have the parent "GO:0140418 effector-mediated modulation of host process by symbiont"?

The reason for this is that in our new PHI-base 5 website we capture high level information about whether the pathogen gene functions as an 'effector'. This information is then provided as a high level term label. The logic to do this involves looking for GO BP terms that are children of "GO:0140418 effector-mediated modulation of host process by symbiont".

[pgaudet]

+[Term]
+id: GO:0141017
+name: effector-mediated induction of cell cycle reactivation in host
+namespace: biological_process
+def: "A symbiont process in which a molecule secreted by the symbiont reactivates the host cell cycle, resulting in DNA synthesis and host cell division, and contributing to vegetative tumor formation." [PMID:25888589]
+is_a: GO:0140418 ! effector-mediated modulation of host process by symbiont
+relationship: part_of GO:0051819 ! induction by symbiont of tumor or growth in host
+property_value: term_tracker_item "#24370" xsd:anyURI
+created_by: pg
+creation_date: 2023-04-04T08:41:31Z