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--- | ||
layout: rule | ||
id: GORULE:0000059 | ||
title: "GAF Version 2.1 should have Qualifiers upgraded based on the GO Term" | ||
type: repair | ||
fail_mode: soft | ||
status: proposed | ||
tags: [] | ||
contact: "go-quality@mailman.stanford.edu" | ||
--- | ||
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When processing GAF version 2.1, if the qualifier field (column 4) does not have a relation | ||
a relation should be computed based on the following rule: | ||
* If the annotation GO Term is in `molecular function` then the relation should be `RO:0002327 "enables"` | ||
* If the annotation GO Term is in `biological process` then the relation should be `RO:0002264 "acts upstream or within"` | ||
* If the annotation GO Term is in `cellular component` then | ||
* If the GO Term is a subclass of `"GO:0032991 "protein-containing complex"` then the relation should be `"BFO:0000050 "part of"` | ||
* Otherwise the relation should be `RO:0001025 "located in"` | ||
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This is due to the other annotation formats having a richer set of Relations available to them. In order to interoperate between GAF 2.1 | ||
and other formats as other formats have a richer set of allowed relations, this will be a process to provide basic compatibility. |