Data collections for Drug set enrichment analysis (DTSEA)

DTSEA contains the basic R functions and sample data for running the DTSEA algorithm. After installing and loading the package, users will be able to explore the framework of DTSEA.

This package provides supplementary data for DTSEA. The data package contains full disease-related gene list of GSE183071, full network list, and other useful supplementary data for exploring DTSEA.

Getting started

List of the supplementary datasets

Data name	Description
deletion	Drug prediction results on trimmed graphs after enrichment
drug_indications	The drug indications data from ChEMBL
drug_predicted	The drug target data predicted by ChEMBL
drug_targets	The combined drug target data
expr_raw	The raw expression profile of GSE164805
graph	The human gene functional interaction network we used
ncbi_list	The COVID-19-related genes provided by NCBI

Installation and examples

# Install the required packages
if (!"devtools" %in% as.data.frame(installed.packages())$Package)
  install.packages("devtools")
devtools::install_github(c("hanjunwei-lab/DTSEA", "hanjunwei-lab/DTSEAdata"))
library(DTSEA)

# Load some data
data("drug_indications")

# Randomly load three datasets
library(dplyr)
data(package = "DTSEAdata")$results[, "Item"] %>%
  sample(3) %>%
  data(list = .)