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boaguilar committed Feb 11, 2022
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The Synthetic Lethality resource
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Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of
two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in
cancer, as exemplified by the recent success of PARP inhibitors in treating BRCA1/2-deficient
tumors. We present SL-Cloud, an cloud based integrated resource to facilitate the prediction
of context-specific SLIs. This resource addresses two main
challenges related to SLI inference: the need to wrangle and preprocess large multi-omic
datasets and the multiple comparable prediction approaches available.

SL-Cloud provides a cloud-based data access platform coupled with software and well documented
computational notebooks that re-implement published synthetic lethality (SL) inference algorithms to
facilitate novel investigation into synthetic lethality. In addition, we provide general purpose
functions that support these prediction workflows e.g. saving data in bigquery tables.
We anticipate that users can leverage the resources provided in this project
to conduct highly customizable analysis based on their cancer type of interest and particular context.

More information of SL-Cloud can be found in the following links:

- `Notebooks in MyBinder <https://mybinder.org/v2/gh/boaguilar/SL-Cloud/HEAD>`_
- `GitHub Repository <https://github.com/IlyaLab/SL-Cloud/>`_
- `Article describing SL-cloud <https://www.biorxiv.org/content/10.1101/2021.09.18.459450v1.abstract>`_




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