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The Synthetic Lethality resource | ||
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Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of | ||
two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in | ||
cancer, as exemplified by the recent success of PARP inhibitors in treating BRCA1/2-deficient | ||
tumors. We present SL-Cloud, an cloud based integrated resource to facilitate the prediction | ||
of context-specific SLIs. This resource addresses two main | ||
challenges related to SLI inference: the need to wrangle and preprocess large multi-omic | ||
datasets and the multiple comparable prediction approaches available. | ||
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SL-Cloud provides a cloud-based data access platform coupled with software and well documented | ||
computational notebooks that re-implement published synthetic lethality (SL) inference algorithms to | ||
facilitate novel investigation into synthetic lethality. In addition, we provide general purpose | ||
functions that support these prediction workflows e.g. saving data in bigquery tables. | ||
We anticipate that users can leverage the resources provided in this project | ||
to conduct highly customizable analysis based on their cancer type of interest and particular context. | ||
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More information of SL-Cloud can be found in the following links: | ||
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- `Notebooks in MyBinder <https://mybinder.org/v2/gh/boaguilar/SL-Cloud/HEAD>`_ | ||
- `GitHub Repository <https://github.com/IlyaLab/SL-Cloud/>`_ | ||
- `Article describing SL-cloud <https://www.biorxiv.org/content/10.1101/2021.09.18.459450v1.abstract>`_ | ||
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