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The transients are stored in wp_options with autoload='yes'. This means if you're storing a lot of different TLC transients with a lot of data (e.g. fetching and caching many URLs), Wordpress will take long to load all the options with autoload='yes' (including the transients), which can cause performance issues.
I think it would be better to store the transients with autoload='no'. Unfortunately, I didn't see a quick fix, because the WordPress transients API only sets autoload when an explicit expiration is set.