This example shows a famous case of a two dimensional potential used to test new methods of enhanced sampling. The bias uses regular grid of gaussians with variable height.
Similar to the previous case but two more harmonic DOFs are added to make things more difficult. The method needs to identify the most importand DOFs and bias along them.
Using modified torchmd package, we investigate Alanine dipeptide dynamics. The forcefield used is ff19SB from amber package.