Pravastatin model

This repository provides the pravastatin physiological based pharmacokinetics model (PBPK).

The model is distributed as SBML available from pravastatin_body_flat.xml with corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/pravastatin-model/main/models/pravastatin_body_flat.xml

Comp submodels

The liver submodel is available from pravastatin_liver.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/pravastatin-model/main/models/pravastatin_liver.xml

The kidney submodel is available from pravastatin_kidney.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/pravastatin-model/main/models/pravastatin_kidney.xml

The intestine submodel is available from pravastatin_intestine.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/pravastatin-model/main/models/pravastatin_intestine.xml

The whole-body submodel is available from pravastatin_body.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/pravastatin-model/main/models/pravastatin_body.xml

How to cite

König, Matthias, & Leal Pujol, Helen. (2022).
Pravastatin physiological based pharmacokinetics model (PBPK)
Zenodo. https://doi.org/10.5281/zenodo.6420970

License

• Source Code: LGPLv3
• Documentation: CC BY-SA 4.0
• Models: CC BY-SA 4.0

The pravastatin-model source is released under both the GPL and LGPL licenses version 2 or later. You may choose which license you choose to use the software under.

This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License or the GNU Lesser General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

Funding

Matthias König is supported by the Federal Ministry of Education and Research (BMBF, Germany) within the research network Systems Medicine of the Liver (LiSyM, grant number 031L0054) and by the German Research Foundation (DFG) within the Research Unit Programme FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643.

© 2021-2022 Matthias König