Pulse-SILAC has been used to analyze protein turnover in a system-wise. This package provides convenient functions to fit protein degradation and synthesis curves using pulsed SILAC data. In addition, a graphical user interface is provided.

Install the package:

library(devtools)
install_github("mengchen18/proturn")

A vignette could be find: https://mengchen18.github.io/2018/01/30/proturn-workflow.html

A tutorial about the Shiny app could be find: https://mengchen18.github.io/2018/01/30/proturn-shiny.html

Citation: If you use this package, please cite: Jana Zecha, Chen Meng, Daniel Paul Zolg, Patroklos Samaras, Mathias Wilhelm and Bernhard Kuster. (2018) Peptide level turnover measurements enable the study of proteoform dynamics. Molecular & Cellular Proteomics