Add functions to add mutations to populations.

doc/misc/changelog.md

@@ -12,6 +12,11 @@ Bug fixes
   {pr}`766`
   {issue}`765`
 
+New features
+
+* Add {func}`fwdpy11.DiploidPopulation.add_mutation`.
+* Add {class}`fwdpy11.NewMutationData`.
+
 C++ back-end
 
 * A population can now be checked that it is- or is not- being simulated.

doc/pages/types.md

@@ -325,6 +325,9 @@ print(fwdpy11.NOGROWTH)
 
     .. autoattribute:: __init__
 
+.. autoclass:: fwdpy11.NewMutationData
+   :members:
+
 ```
 
 

fwdpy11/CMakeLists.txt

@@ -101,6 +101,10 @@ set (ARRAY_PROXY_SOURCES src/array_proxies/init.cc)
 set (MUTATION_DOMINANCE_SOURCES src/mutation_dominance/init.cc
      src/mutation_dominance/MutationDominance.cc)
 
+set (FUNCTION_SOURCES src/functions/init.cc
+     src/functions/add_mutation.cc
+     src/functions/_add_mutation.cc)
+
 set(ALL_SOURCES ${FWDPP_TYPES_SOURCES}
     ${FWDPY11_TYPES_SOURCES}
     ${REGION_SOURCES}
@@ -112,7 +116,8 @@ set(ALL_SOURCES ${FWDPP_TYPES_SOURCES}
     ${EVOLVE_POPULATION_SOURCES}
     ${DISCRETE_DEMOGRAPHY_SOURCES}
     ${ARRAY_PROXY_SOURCES}
-    ${MUTATION_DOMINANCE_SOURCES})
+    ${MUTATION_DOMINANCE_SOURCES}
+    ${FUNCTION_SOURCES})
 
 set(LTO_OPTIONS)
 if(ENABLE_PROFILING OR DISABLE_LTO)

fwdpy11/__init__.py

@@ -75,6 +75,7 @@
     DiploidPopulation,
     TreeIterator,
     VariantIterator,
+    NewMutationData,
 )  # NOQA
 from ._types.demography_debugger import DemographyDebugger  # NOQA
 from ._types.model_params import ModelParams, MutationAndRecombinationRates  # NOQA

fwdpy11/_types/__init__.py

@@ -27,3 +27,4 @@
 from .data_matrix_iterator import DataMatrixIterator  # NOQA
 from .diploid_population import DiploidPopulation  # NOQA
 from .model_params import ModelParams  # NOQA
+from .new_mutation_data import NewMutationData  # NOQA

fwdpy11/_types/diploid_population.py

@@ -9,6 +9,7 @@
 
 from .._fwdpy11 import DiploidGenotype, DiploidMetadata, ll_DiploidPopulation
 from .model_params import ModelParams
+from .new_mutation_data import NewMutationData
 from .population_mixin import PopulationMixin
 from .table_collection import TableCollection
 
@@ -321,3 +322,84 @@ def sample_timepoints(
             md.flags.writeable = False
             nodes.flags.writeable = False
             yield self.generation, nodes, md
+
+    def add_mutation(
+        self,
+        rng: fwdpy11.GSLrng,
+        *,
+        window: Tuple[float, float] = None,
+        ndescendants: int = 1,
+        deme: Optional[int] = None,
+        data: NewMutationData = None,
+    ) -> Optional[int]:
+        """
+        Add a new mutation to the population.
+
+        .. versionadded:: 0.16.0
+
+        :param rng: Random number generator
+        :type rng: fwdpy11.GSLrng
+
+        The following arguments are keyword-only:
+
+        :param window: A window [left, right) within which to place the mutation.
+                       The default is `None`, meaning the window is the entire
+                       genome.
+        :type window: tuple[float, float]
+        :param ndescendants: The number of alive nodes carrying the new mutation.
+                             Default is `1`, implying that a singleton mutation
+                             will be generated.
+        :type ndescendants: int
+        :param deme: The deme in which to place the new mutation
+                     The default is `None`, meaning that alive node demes are
+                     not considered.
+        :type deme: int
+        :type data: The details of the new mutation
+        :type data: fwdpy11.NewMutationData
+
+        :returns: The key of the new mutation.
+                  (The index of the variant in :attr:`DiploidPopulation.mutations`.)
+
+        Implementation details:
+
+        * A set of nodes are found within `window` that are ancestral to
+          exactly `ndescendants` alive nodes.
+        * From this list of candidate nodes, one is chosen randomly
+          to be the node where we place the new mutation.
+        * This node's time is the origin time of the new mutation.
+        * If `deme` is None, any set of `ndescendants` will be considered.
+        * If `deme` is :math:`\geq 0`, all `ndescendants` alive nodes must be
+          from that deme.
+        * If the `deme`/`ndescendants` requirements cannot be satisified,
+          the function returns `None`.
+        * The genetic values of individuals are not updated by this function.
+          Such updates will happen when the population begins evolution
+          forwards in time.
+
+        Exceptions:
+
+        :raises ValueError: for bad input.
+        :raises RuntimeError: if this function is applied during a simulation
+        :raises RuntimeError: if internal checks fail.
+        """
+        if window is None:
+            _window = (0.0, self.tables.genome_length)
+        else:
+            _window = window
+
+        if deme is None:
+            _deme = -1
+        else:
+            _deme = deme
+
+        if ndescendants is None:
+            raise ValueError(f"ndescendants must be > 0: got {ndescendants}")
+
+        from fwdpy11._fwdpy11 import _add_mutation
+
+        key = _add_mutation(
+            rng, _window[0], _window[1], ndescendants, _deme, data, self
+        )
+        if key == np.iinfo(np.uint64).max:
+            return None
+        return key

fwdpy11/_types/new_mutation_data.py

@@ -0,0 +1,50 @@
+import typing
+
+import attr
+
+from .._fwdpy11 import ll_NewMutationData
+
+
+@attr.s(auto_attribs=True, frozen=True, repr_ns="fwdpy11", kw_only=True)
+class NewMutationData(ll_NewMutationData):
+    """
+    Data object for :func:`fwdpy11.DiploidPopulation.add_mutation`
+
+    .. versionadded:: 0.16.0
+
+    This class has the following attributes, whose names
+    are also `kwargs` for intitialization.  The attribute names
+    also determine the order of positional arguments:
+
+    :param effect_size: The fixed/univariate effect size.
+                        Will fill in :attr:`fwdpy11.Mutation.s`
+    :type effect_size: float
+    :param dominance: Heterozygous effect of the mutation.
+                      Will fill in :attr:`fwdpy11.Mutation.h`
+    :type dominance: float
+    :param esizes: Data to fill :attr:`fwdpy11.Mutation.esizes`.
+                   Default is `None`.
+    :type esizes: list[float]
+    :param heffects: Data to fill :attr:`fwdpy11.Mutation.heffects`.
+                     Default is `None`.
+    :type heffects: list[float]
+    :param label: Data for :attr:`fwdpy11.Mutation.label`.
+                  Default is 0.
+    :type label: int
+    """
+
+    effect_size: float
+    dominance: float
+    esizes: typing.Optional[typing.List[float]] = None
+    heffects: typing.Optional[typing.List[float]] = None
+    label: int = 0
+
+    def __attrs_post_init__(self):
+        if self.esizes is None and self.heffects is None:
+            super(NewMutationData, self).__init__(
+                self.effect_size, self.dominance, [], [], self.label
+            )
+        else:
+            super(NewMutationData, self).__init__(
+                self.effect_size, self.dominance, self.esizes, self.heffects, self.label
+            )

fwdpy11/src/_fwdpy11.cc

@@ -22,6 +22,7 @@ void init_ts(py::module &);
 void init_evolution_functions(py::module &);
 void init_discrete_demography(py::module &m);
 void init_array_proxies(py::module &m);
+void initialize_functions(py::module & m);
 
 PYBIND11_MODULE(_fwdpy11, m)
 {
@@ -37,6 +38,7 @@ PYBIND11_MODULE(_fwdpy11, m)
     init_evolution_functions(m);
     init_discrete_demography(m);
     init_array_proxies(m);
+    initialize_functions(m);
 
     py::register_exception<fwdpy11::GSLError>(m, "GSLError");
 

fwdpy11/src/functions/_add_mutation.cc

@@ -0,0 +1,34 @@
+//
+// Copyright (C) 2021 Kevin Thornton <krthornt@uci.edu>
+//
+// This file is part of fwdpy11.
+//
+// fwdpy11 is free software: you can redistribute it and/or modify
+// it under the terms of the GNU General Public License as published by
+// the Free Software Foundation, either version 3 of the License, or
+// (at your option) any later version.
+//
+// fwdpy11 is distributed in the hope that it will be useful,
+// but WITHOUT ANY WARRANTY; without even the implied warranty of
+// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+// GNU General Public License for more details.
+//
+// You should have received a copy of the GNU General Public License
+// along with fwdpy11.  If not, see <http://www.gnu.org/licenses/>.
+//
+#include <pybind11/pybind11.h>
+#include <pybind11/stl.h>
+#include "add_mutation.hpp"
+
+namespace py = pybind11;
+
+void
+init_add_mutation(py::module& m)
+{
+    m.def("_add_mutation", &add_mutation);
+
+    py::class_<new_mutation_data>(m, "ll_NewMutationData")
+        .def(py::init<double, double, std::vector<double>, std::vector<double>,
+                      decltype(fwdpy11::Mutation::xtra)>());
+}
+