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Welcome to the service-epitope wiki!

This service reports on HLA-DPB1 alleles and their associated immunogenicity groups and provides matching functions. The immunogenicity groups are assigned by crossreactivity patterns of T-cells alloreactive to DPB1*09:01. To learn more about this checkout this paper.

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DPB1 TCE Matching Overview

DPB1 alleles are classified by immunogeneticity into 3 groups. Numbers indicate the group of the HLA-DPB1 alleles of the donor or of the recipient. Classification of HLA-DPB1 mismatches as permissive or non permissive in GvH or in HvG direction is indicated for all possible combinations.

DPB1 T-Cell Epitope Matching Status

• MATCH: Includes donors with DPB1 alleles that are either allele matched or antigen recognition site matched to the patient’s alleles.
• PERMISSIVE: Includes donors with DPB1 alleles considered to be permissive (do not result in a poor clinical outcome) to the patient’s alleles.
• NON-PERMISSIVE: includes donors with DPB1 alleles considered to be non-permissive (do result in a poor clinical outcome) to the patient’s alleles in either host vs graft direction or the graft vs host direction.
  • HVG_NONPERMISSIVE: Host vs Graft non-permissive mismatch
  • GVH_NONPERMISSIVE: Graft vs Host non-permissive mismatch
• POTENTIAL: includes donors where the final match assignment cannot be determined without further typing.

Related Links:

• https://bioinformatics.bethematchclinical.org/
• https://ghr.nlm.nih.gov/gene/HLA-DPB1