[NTR] endometrial ciliated cell

[s-carney]

Note - please check that the term does not already exist (check OLS: https://www.ebi.ac.uk/ols/ontologies/cl)

Preferred term label
endometrial ciliated cell

Synonyms (add reference(s), please)
ciliated cell of the endometrium
uterine ciliated cell
ciliated cell of the uterus

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A ciliated cell that lines the endometrium where the cilia help move mucus from the glandular tissue [PMID: 31290979]

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl)
http://purl.obolibrary.org/obo/CL_0000064

What is the anatomical structure that the cell is a part of? (check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon)
http://purl.obolibrary.org/obo/UBERON_0004811

[ghost]

Thanks for the new term request, @s-carney.

In another ticket (#1760), it is planned to add 3 new terms (from https://www.nature.com/articles/s41591-020-1040-z):

‘endometrial ciliated epithelial cell’
with new child classes:
‘luminal endometrial ciliated epithelial cell’
‘glandular endometrial ciliated epithelial cell’

If you agree, I will merge the details from this request with creating the new term ‘endometrial ciliated epithelial cell’.

[s-carney]

Hello, thanks for your response. I agree the other tickets describes well the term suggested.

[ghost]

Thanks for the reply, @s-carney.
The reference provided also uses organoids in the study, which is outside the domain of CL.
If you'd like to have your requested synonyms added to the new term, a non-organoid reference or your ORCID could be added to support their inclusion.

[s-carney]

My primary source was the Human Protein Atlas:
https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells
Perhaps if this is not sufficient, I can find another reference.

[ghost]

Propose to add the following 3 new terms:

Preferred term label
endometrial ciliated epithelial cell

Synonyms (add reference(s), please)
ciliated cell of the endometrium (exact)
endometrium ciliated epithelial cell (exact)
uterine ciliated cell (broad)
ciliated cell of the uterus (broad)

Definition
A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium.
https://www.nature.com/articles/s41591-020-1040-z
https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells

EA
'epithelial cell' and 'ciliated cell’ and 'part of' some 'endometrium epithelium'

Comment
In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted.
https://www.nature.com/articles/s41591-020-1040-z

---

Preferred term label
luminal endometrial ciliated epithelial cell

Synonyms
n/a

Definition
A ciliated cell of the endometrial luminal epithelium.
https://www.nature.com/articles/s41591-020-1040-z

Parents
'endometrial ciliated epithelial cell’
'part of' some ‘endometrium luminal epithelium’ (UBERON term to be imported)

---

Preferred term label
glandular endometrial ciliated epithelial cell

Synonyms (add reference(s), please)
n/a

Definition
A ciliated cell of the endometrial glandular epithelium.
https://www.nature.com/articles/s41591-020-1040-z

Parents
'endometrial ciliated epithelial cell’
'part of' some ‘endometrium glandular epithelium’

[ghost]

@s-carney,

Thank you for this ticket. The following have been added to CL and should appear in the next release:

CL:4030040 ‘endometrial ciliated epithelial cell’
CL:4030041 ‘luminal endometrial ciliated epithelial cell’
CL:4030042 ‘glandular endometrial ciliated epithelial cell’

More details are available in the linked PR.