Computational modeling of signaling pathways in cancer

The Emergent Integrated Circuit of the Cell

Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000). https://doi.org/10.1016/S0092-8674(00)81683-9

Models

• ErbB signaling pathway

  • Kholodenko1999
  • Hatakeyama2003
  • Birtwistle2007
  • Hass2017

• Insulin signaling pathway

  • Kubota2012

• Immediate-early gene response

  • Nakakuki2010

• NF-κB pathway

  • Lipniacki2004
  • Shinohara2014
  • Inoue2016
  • Oppelt2018

• Cell cycle

  • Hegarat2014
  • Barr2016
  • Heldt2018

• TGF-β/Smad signaling pathway

  • Zi2011
  • Lucarelli2018

• JAK/STAT signaling pathway

  • Raia2011

• p38 MAPK pathway

  • Tomida2015

• DNA damage response pathway

  • Yang2018

License

MIT