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Fix conversion fuction #158

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Fix conversion fuction #158

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LorenzoMerotto
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Update of conversion function between mouse and human genes
Addition of custom deconvolution with seqimmucc
Fixing minor bugs (#156 )

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github-actions bot commented Nov 17, 2023

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@LorenzoMerotto
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@grst do you have an idea about what's wrong here? I assumed we needed to update the version of conda but this looks already like the latest one

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@LorenzoMerotto
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@grst I'm waiting to merge to see what you think about that

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Sorry, I missed your comment about conda in all the github notifications.

I have a couple of questions, but looks good otherwise

@@ -29,7 +29,7 @@ custom_deconvolution_methods <- c(
"EPIC" = "epic",
"CIBERSORT" = "cibersort",
"ConsensusTME" = "consensus_tme",
"BASE" = "base"
"seqImmuCC" = "seqimmucc"
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What happened to BASE?

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Removing a method is a breaking change that should only happen with a good reason (+ major version bump + explanation in changelog)

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I'm not removing a method here, I'm just removing the possibility to use it with a custom matrix (this is due to an error in my implementation)

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all good then

Comment on lines 334 to 335
rownames <- Reduce(intersect, lapply(list.results, rownames))
list.results <- lapply(list.results, function(x) x[rownames, ])
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Why? And wouldn't you rather want an "outer" join with NAs (or 0s) in places where individual samples don't have a cell-type?

Maybe add a comment, why this was necessary to understand this better in the future.

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Could be another solution too

@@ -124,26 +124,28 @@ In addition, human-based methods can be used to deconvolute mouse data through t
to the corresponding human orthologues

```R
gene_expression_matrix <- immunedeconv::mouse_genes_to_human(gene_expression_matrix)
gene_expression_matrix <- immunedeconv::convert_human_mouse_genes(gene_expression_matrix, convert_to = "human")
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Did I get this right that the function wasn't renamed, but just the wrong function reference from the tutorial?

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The function was renamed because instead of going from mouse genes to human, now it can go both ways

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This is also a breaking change then... Usually what is done in such cases is to keep the old function as an alias to the new one (provided that it has a compatible signature) and show a deprecation warning when it is still used.

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2 participants