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UPDATE: addition July 2022 release notes + RN tweak
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|---|---|---|
| @@ -1,13 +1,13 @@ | ||
| <ul> | ||
| <li>Updated GPCR annotated <a href="/structure/">structures</a> and it's encompassing browser and accordingly | ||
| updated <a href="/structure/statistics">statistics</a>.</li> | ||
| updated <a href="/structure/statistics">statistics</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure | ||
| models.</li> | ||
| <li>Updated GPCR-G protein complex structure <a href="/structure/complex_models">models</a>.</li> | ||
| <li>Updated <a href="/ligand">ligand</a> database.</li> | ||
| <li>New and faster phylogenetic tree tool.</li> | ||
| <li>New easy citation tool.</li> | ||
| <li>New join us tool.</li> | ||
| <li>Updated menu layout.</li> | ||
| models</li> | ||
| <li>Updated GPCR-G protein complex structure <a href="/structure/complex_models">models</a></li> | ||
| <li>Updated <a href="/ligand">ligand</a> database</li> | ||
| <li>New and faster phylogenetic tree tool</li> | ||
| <li>New easy citation tool</li> | ||
| <li>New join us tool</li> | ||
| <li>Updated menu layout</li> | ||
| </ul> | ||
|
|
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|---|---|---|
| @@ -1,6 +1,6 @@ | ||
| <ul> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> | ||
|
|
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|---|---|---|
| @@ -1,7 +1,7 @@ | ||
| <ul> | ||
| <li>New <a href="/protein/isoforms">Isoforms resource</a> accompanying the publication of <a href="https://www.nature.com/articles/s41586-020-2888-2" target="_blank">this Nature article</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>New <a href="/protein/isoforms">Isoforms resource</a> accompanying the publication of <a href="https://www.nature.com/articles/s41586-020-2888-2" target="_blank">this Nature article</a></li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> | ||
|
|
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|---|---|---|
| @@ -1,14 +1,14 @@ | ||
| <ul> | ||
| <li>Accompanying our 2021 GPCRdb publication in <a href="https://doi.org/10.1093/nar/gkaa1080">Nucleic Acids Research</a> are:</li> | ||
| <ul> | ||
| <li>A new receptor selection page (present in e.g. <a href="/alignment/targetselection">sequence alignments</a>).</li> | ||
| <li><a href="/structure/model_statistics">Receptor model statistics page</a> analyzing the accuracy of our models upon release of experimental structures.</li> | ||
| <li>A new receptor selection page (present in e.g. <a href="/alignment/targetselection">sequence alignments</a>)</li> | ||
| <li><a href="/structure/model_statistics">Receptor model statistics page</a> analyzing the accuracy of our models upon release of experimental structures</li> | ||
| </ul> | ||
| <li>Official release of the <a href="/protein/ste2_yeast/">class D1 numbering system</a> accompanying the <a href="https://www.nature.com/articles/s41586-020-2994-1" target="_blank">Nature publication</a> of the first structure of a class D GPCR.</li> | ||
| <li>Official release of the <a href="/protein/ste2_yeast/">class D1 numbering system</a> accompanying the <a href="https://www.nature.com/articles/s41586-020-2994-1" target="_blank">Nature publication</a> of the first structure of a class D GPCR</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a> - now up to a total of 500!</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Updated GPCR species orthologs from UniProt.</li> | ||
| <li>Updated documentation.</li> | ||
| <li>Updated references.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Updated GPCR species orthologs from UniProt</li> | ||
| <li>Updated documentation</li> | ||
| <li>Updated references</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,7 +1,7 @@ | ||
| <ul> | ||
| <li>Added G protein structures not in complex with GPCRs to the <a href="/structure/g_protein_structure_browser">G protein structure browser</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Updated documentation.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Added G protein structures not in complex with GPCRs to the <a href="/structure/g_protein_structure_browser">G protein structure browser</a></li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Updated documentation</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,6 +1,6 @@ | ||
| <ul> | ||
| <li>Improved structure download and superpositioning workflow.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Improved structure download and superpositioning workflow</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,8 +1,8 @@ | ||
| <ul> | ||
| <li>Improved tree visualizations on all statistics pages.</li> | ||
| <li>Updated <a href="/structure/">GPCR</a> and <a href="/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Added community-contributed <a href="/mutations">mutation data</a>.</li> | ||
| <li>Updated references.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Improved tree visualizations on all statistics pages</li> | ||
| <li>Updated <a href="/structure/">GPCR</a> and <a href="/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Added community-contributed <a href="/mutations">mutation data</a></li> | ||
| <li>Updated references</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,5 +1,5 @@ | ||
| <ul> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,5 +1,5 @@ | ||
| <ul> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,5 +1,5 @@ | ||
| <ul> | ||
| <li>Updated GPCR <a href="/structure/">structures</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated GPCR <a href="/structure/">structures</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,8 +1,8 @@ | ||
| <ul> | ||
| <li>Official release of the research hub: <a href="https://gpcrdb.org/">GPCRdb</a>, <a href="https://gproteindb.org/">GproteinDb</a>, and <a href="https://arrestindb.org/">ArrestinDb</a>.</li> | ||
| <li>Extension of the <a href="https://gproteindb.org/signprot/couplings">G protein</a> and <a href="https://arrestindb.org/signprot/arrestincouplings">Arrestin</a> couplings with new data and new functionalities.</li> | ||
| <li>Updated <a href="https://docs.gpcrdb.org">documentation</a>.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Official release of the research hub: <a href="https://gpcrdb.org/">GPCRdb</a>, <a href="https://gproteindb.org/">GproteinDb</a>, and <a href="https://arrestindb.org/">ArrestinDb</a></li> | ||
| <li>Extension of the <a href="https://gproteindb.org/signprot/couplings">G protein</a> and <a href="https://arrestindb.org/signprot/arrestincouplings">Arrestin</a> couplings with new data and new functionalities</li> | ||
| <li>Updated <a href="https://docs.gpcrdb.org">documentation</a></li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,6 +1,6 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Updated <a href="https://docs.gpcrdb.org">documentation</a>.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Updated <a href="https://docs.gpcrdb.org">documentation</a></li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,5 +1,5 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,4 +1,4 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,6 +1,6 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR-G protein complex structure <a href="/structure/complex_models">models</a>.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR-G protein complex structure <a href="/structure/complex_models">models</a></li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,20 +1,20 @@ | ||
| <ul> | ||
| <li>Release of the new Biased Signalling resource</li> | ||
| <ul> | ||
| <li>Bias calculations according to the recently published <a href="https://doi.org/10.1111/bph.15811" target="_blank">Community Guidelines for GPCR Ligand Bias</a>.</li> | ||
| <li>In-depth browsing and plotting of biased signalling data for individual receptors on transducer family and subtype level.</li> | ||
| <li>Visualisation of the trends in the signalling data via the <a href="https://gpcrdb.org/biased_signalling/bias_statistics"> statistics</a> pages.</li> | ||
| <li>Annotation of endogenous ligands via the Guide to Pharmacology for identifying physiology-biased ligands.</li> | ||
| <li>Comparison of receptor-signalling profiles between any ligand with signalling data for a given receptor.</li> | ||
| <li>Bias calculations according to the recently published <a href="https://doi.org/10.1111/bph.15811" target="_blank">Community Guidelines for GPCR Ligand Bias</a></li> | ||
| <li>In-depth browsing and plotting of biased signalling data for individual receptors on transducer family and subtype level</li> | ||
| <li>Visualisation of the trends in the signalling data via the <a href="https://gpcrdb.org/biased_signalling/bias_statistics"> statistics</a> pages</li> | ||
| <li>Annotation of endogenous ligands via the Guide to Pharmacology for identifying physiology-biased ligands</li> | ||
| <li>Comparison of receptor-signalling profiles between any ligand with signalling data for a given receptor</li> | ||
| </ul> | ||
| <li>Revamped ligand handling in GPCRdb</li> | ||
| <ul> | ||
| <li>Improved ligand identification, processing, curation, integration, and crosslinking.</li> | ||
| <li>Updated GPCR ligand and bioactivity data from ChEMBL.</li> | ||
| <li>Updated ligand vendor data from PubChem.</li> | ||
| <li>Improved ligand identification, processing, curation, integration, and crosslinking</li> | ||
| <li>Updated GPCR ligand and bioactivity data from ChEMBL</li> | ||
| <li>Updated ligand vendor data from PubChem</li> | ||
| <li>Linking ligands to external sources (<a href="https://www.guidetopharmacology.org" target="_blank">Guide to Pharmacology</a>, <a href="https://www.ebi.ac.uk/chembl/" target="_blank">ChEMBL</a>, <a href="https://pubchem.ncbi.nlm.nih.gov" target="_blank">PubChem</a>, <a href="https://drugcentral.org" target="_blank">Drug Central</a>, and <a href="https://www.drugbank.ca" target="_blank">DrugBank</a>). </li> | ||
| </ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="https://gpcrdb.org/structure/homology_models">homology</a> and <a href="https://gpcrdb.org/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="https://gpcrdb.org/structure/homology_models">homology</a> and <a href="https://gpcrdb.org/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,6 +1,6 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR ligand and bioactivity data to <a href="https://www.ebi.ac.uk/chembl/" target="_blank">ChEMBL</a> v30.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR ligand and bioactivity data to <a href="https://www.ebi.ac.uk/chembl/" target="_blank">ChEMBL</a> v30</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -1,5 +1,5 @@ | ||
| <ul> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures.</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models.</li> | ||
| <li>Minor bug and performance fixes.</li> | ||
| <li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
| <li>Updated GPCR <a href="/structure/homology_models">homology</a> and <a href="/structure/">refined</a> structure models</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,8 @@ | ||
| <ul> | ||
| <li>New <a href="https://gpcrdb.org/ligand/endogenousbrowser/">Endogenous ligands browser</a></li> | ||
| <li>New ligand information page, click here for <a href="https://gpcrdb.org/ligand/134/info">an example</a></li> | ||
| <li>Adding GPCR ligands from the <a href="https://www.guidetopharmacology.org/" target="_blank">Guide to Pharmacology</a></li> | ||
| <li>Adding GPCR ligands from the <a href="https://pdsp.unc.edu/databases/kidb.php" target="_blank">PDSP K<sub>i</sub> database</a></li> | ||
| <li>Updated layout for the main page and the menu system</li> | ||
| <li>Minor bug and performance fixes</li> | ||
| </ul> |