IGoR: Inference and Generation Of Repertoires

This repository contains all sources and models useful to infer V(D)J recombination related processes for TCR or BCR sequencing data using IGoR.

IGoR’s exhaustive documentation can be found here!

Download the latest release here.

Quick summary

IGoR is a C++ software designed to infer V(D)J recombination related processes from sequencing data such as:

• Recombination model probability distribution

• Hypermutation model

• Best candidates recombination scenarios

• Generation probabilities of sequences (even hypermutated)

The following paper describes the methodology, performance tests and some new biological results obtained with IGoR:

High-throughput immune repertoire analysis with IGoR, Nature Communications, (2018) Quentin Marcou, Thierry Mora, Aleksandra M. Walczak

Its heavily object oriented and modular style was designed to ensure long term support and evolvability for new tasks in assessing TCR and BCR receptors features using modern parallel architectures.

IGoR is a free (as in freedom) software released under the GNU-GPLv3 license.

Version

./docs/asciidoc/version.adoc Download the latest release here.

Documentation

A comprehensive documentation of IGoR is available on the internet at: http://qmarcou.github.io/IGoR or in your local installation of IGoR as the ./docs/index.html file.

./docs/asciidoc/general/contribute.adoc

Contact

For any question or issue please open an issue or email us.

Copying

Free use of IGoR is granted under the terms of the GNU General Public License version 3 (GPLv3).