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XBB.1.16 ( Pango #1920 sublineage) with ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) #77

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c19850727 opened this issue May 20, 2023 · 3 comments
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XBB.1.16 ( Pango #1920 sublineage) with ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) #77

c19850727 opened this issue May 20, 2023 · 3 comments
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Mutations outside spike New mutations Lineage with an unusual/new/interesting mutation

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@c19850727
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This cluster obtained 2 ORF9b changes in a stepwise manner, including a 2-nuc mutation that further changed ORF9b:5T into ORF9b:5A.

image
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3bb1b_8c4a30.json?c=userOrOld&label=id:node_8419324

changes on top of XBB.1.16: A28353T (N:27I / ORF9b:T24S) > C13548T > A27142G (M:N207S) > T26418C > G3485A (ORF1a:A1074T) > G12355A, C14184T, G20491T (ORF1b:V2342L), A28296G (N:N8S / ORF9b:T5A)

Query: G12355A, C14184T, G20491T, A28296G

Genomes: EPI_ISL_17611679, EPI_ISL_17641177, EPI_ISL_17641668, EPI_ISL_17641734-17641735, EPI_ISL_17641803, EPI_ISL_17641810-17641811, EPI_ISL_17687659, EPI_ISL_17687689, EPI_ISL_17687696, EPI_ISL_17688223-17688224
@c19850727 c19850727 changed the title XBB.1.16 with multiple ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) XBB.1.16 with ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) May 20, 2023
@FedeGueli FedeGueli added New mutations Lineage with an unusual/new/interesting mutation Rapid review needed Mutations outside spike labels May 20, 2023
@FedeGueli
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FedeGueli commented May 20, 2023 •
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It has a change on the key extra spike residue at this moment. @c19850727 please propose it if it reaches 20.

@aviczhl2
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We shall first designate the orf9b:T24S, it is steadily growing. cov-lineages/pango-designation#1820

@FedeGueli FedeGueli changed the title XBB.1.16 with ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) XBB.1.16 ( Pango #1920 sublineage) with ORF9b:T5A and ORF9b:T24S (13 seqs, Canada-QC) May 31, 2023
@FedeGueli
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This has gone stale so likely T>A at Orf9b:5 wasnt beneficial!

@FedeGueli FedeGueli closed this as not planned Won't fix, can't repro, duplicate, stale Jun 10, 2023
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@aviczhl2 @c19850727 @FedeGueli