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Plugin for continuous conformational flexibility analysis containing HEMNMA and StructMap
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ContinuousFlex plugin

This plugin provides HEMNMA and StructMap protocols and is frequently updated.


You will need to use 2.0 version of Scipion to be able to run these protocols. To install the plugin, you have two options:

  1. Stable version

    scipion installp -p scipion-em-continuousflex
  2. Developer's version

    • download repository
    git clone
    • install
    scipion installp -p path_to_scipion-em-continuousflex --devel

continuousflex sources will be downloaded automatically with the plugin, but you can also link an existing installation.

Note: Xmipp plugin should be installed to run continuousflex.

Supported versions



  • HEMNMA: Hybrid Electron-Microscopy Normal-Mode-Analysis
  • StructMap: Structural Mapping


  1. Jin Q, Sorzano CO, de la Rosa-Trevin JM, Bilbao-Castro JR, Nunez-Ramirez R, Llorca O, Tama F,Jonic S: Iterative elastic 3D-to-2D alignment method using normal modes for studying structural dynamics of large macromolecular complexes. Structure 2014, 22:496-506.
  2. Sorzano CO, de la Rosa-Trevin JM, Tama F, Jonic S: Hybrid Electron Microscopy Normal Mode Analysis graphical interface and protocol. J Struct Biol 2014, 188:134-141.
  3. Sanchez Sorzano CO, Alvarez-Cabrera AL, Kazemi M, Carazo JM, Jonic S: StructMap: Elastic Distance Analysis of Electron Microscopy Maps for Studying Conformational Changes. Biophys J 2016, 110:1753-1765.

# scipion-em-continuousflex

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