Raremetal2: A tool for rare variants meta-analysis (c) 2012-2017 Sai Chen, Shuang Feng, Dajiang Liu, Gonçalo Abecasis
For more info, please see wiki page https://genome.sph.umich.edu/wiki/RAREMETAL
Raremetal2 is an updated version of the meta-analysis software Raremetal It is 30% faster than the original version and takes less memory Compatible with old Raremetalworker or rvtest generated summary files
This is still a beta version. Single-variant meta-analysis looks good on T2D and MGI data, but needs more optimizations on group test.
New features:
- new method for unbalanced studies. To toggle that, please specify --useExact
- multi-allelic site meta-analysis enabled. However, if you have Raremetalworker or rvtest covariance files from previous versions, multi-allelic site meta-analysis won't work well in group test because these old covariance files do not record alleles for each site.
- missing data in conditional analysis
Raremetal2 requires libRMath and zlib to be installed on your system.
From the project root, run make to build binaries (will be deposited in bin/).
Run make clean to remove build assets from a previous attempt.
Currently, only Linux operating systems are officially supported.