Does this apply to animals

[zywz12138]

请问把相关的文件（如：pathway，chrom_LD等）替换成动物的，是否就可以用这个软件在动物上进行gwas和单细胞的整合分析？

[dengchunyu]

可以，同时把block_annotation，Genes_by_pathway_kegg，chrom_ld替换成动物的

[auesro]

Hi, I would like to use scPagwas combining GWAS data from human and scRNAseq data from mouse. What would be the steps? If I change the block_annotation，Genes_by_pathway_kegg，chrom_ld files to contain mouse genes but the GWAS is human...it will not work, right?

Thanks!

[dengchunyu]

是的 Augusto Escalante ***@***.***> 于2024年6月21日周五 22:35写道：

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Hi, I would like to use scPagwas combining GWAS data from human and scRNAseq data from mouse. What would be the steps? If I change the block_annotation，Genes_by_pathway_kegg，chrom_ld files to contain mouse genes but the GWAS is human...it will not work, right? Thanks! — Reply to this email directly, view it on GitHub <#23 (comment)>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AILWCUFZVPQIPMMP2YLBLVTZIQ23BAVCNFSM6AAAAABJWCNI7KVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDCOBSHA3TKNZXGI> . You are receiving this because you commented.Message ID: ***@***.***>

[auesro]

Hi @dengchunyu ,

What do you mean?

[dengchunyu]

Human GWAS data only apply to human single cells and cannot be extended to mouse data. Similarly, matching pathway data is not appropriate for this purpose. Augusto Escalante ***@***.***> 于2024年6月26日周三 14:54写道：

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Hi @dengchunyu <https://github.com/dengchunyu> , What do you mean? — Reply to this email directly, view it on GitHub <#23 (comment)>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AILWCUH4M2ZGKVWFIQOVVPLZJJQSBAVCNFSM6AAAAABJWCNI7KVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDCOJQHE2TANZRGY> . You are receiving this because you were mentioned.Message ID: ***@***.***>

[auesro]

Thank you for the clarification @dengchunyu
Then there is no way to use scPagwas with scRNAseq animal data?

[dengchunyu]

If human data is unavailable, single-cell data from mice can be utilized for assistance. Augusto Escalante ***@***.***> 于2024年6月26日周三 15:38写道：

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Thank you for the clarification @dengchunyu <https://github.com/dengchunyu> Then there is no way to use scPagwas with scRNAseq animal data? — Reply to this email directly, view it on GitHub <#23 (comment)>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AILWCUEPSZXNJBFWHHII6FLZJJVW5AVCNFSM6AAAAABJWCNI7KVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDCOJRGAZDKNZSGE> . You are receiving this because you were mentioned.Message ID: ***@***.***>

[auesro]

Ok, how can you do that? How did you do it for the mouse AD data in the paper?