VAC: Advax-CpG (Advax-2, Advax-SM)

[wolfgang-leitner]

Request to add a new vaccine adjuvant as seen in VAC:
https://vac.niaid.nih.gov/view?id=38

Pubmed References:Chemical Nature: (1) combination adjuvant
Mechanism of Action: (1) complement, (2) dendritic cells, (3) other/unknown, (4) TLR9
Immune profile induced: mixed Th1
Other Features/Characteristics: (1) induces CD8 T cells, (2) provides innate protection, (3) anti-inflammatory, (4) promotes antibody affinity maturation, (5) effective in newborns, (6) high stability
By routes: SQ, IM
Point of Contact: Nikolai Petrovsky, Vaxine LTD
https://www.ncbi.nlm.nih.gov/pubmed/?term=33301675
https://www.ncbi.nlm.nih.gov/pubmed/?term=33301675
https://www.ncbi.nlm.nih.gov/pubmed/?term=34069575
https://www.ncbi.nlm.nih.gov/pubmed/?term=32849580

[yongqunh]

Assigned VO ID:
http://purl.obolibrary.org/obo/VO_0005324

[wolfgang-leitner]

Please update name of this adjuvant to "Advax-CpG55.2".
PI has clarified that he is using the terms "Advax-2" and Advax-SM" for all combinations of Advax with a CpG ODN, not just CpG55.2.

[yongqunh]

I see. What about we keep the term Advax-CpG, and then add a new term "Advax-CpG55.2", which wil be a subclass term under Advax-CpG?

[wolfgang-leitner]

Hi Oliver, that’s a good idea! There will be additional Advax-CpG records coming in soon (all using the same Advax (ie, Inulin) but CpGs with different sequences). Thanks! Wolfgang From: Yongqun Oliver He ***@***.***> Sent: Friday, September 24, 2021 12:26 AM To: vaccineontology/VO ***@***.***> Cc: Leitner, Wolfgang (NIH/NIAID) [E] ***@***.***>; Author ***@***.***> Subject: Re: [vaccineontology/VO] VAC: Advax-CpG (Advax-2, Advax-SM) (#562) I see. What about we keep the term Advax-CpG, and then add a new term "Advax-CpG55.2", which wil be a subclass term under Advax-CpG? — You are receiving this because you authored the thread. Reply to this email directly, view it on GitHub<#562 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AVAUNQV54ZP6T6R36CBFRSLUDP4T5ANCNFSM5DENIFZQ>. Triage notifications on the go with GitHub Mobile for iOS<https://apps.apple.com/app/apple-store/id1477376905?ct=notification-email&mt=8&pt=524675> or Android<https://play.google.com/store/apps/details?id=com.github.android&referrer=utm_campaign%3Dnotification-email%26utm_medium%3Demail%26utm_source%3Dgithub>.

[yongqunh]

Hi Wolfgang, That’s good. I will implement this idea then. Thanks, Oliver From: Wolfgang Leitner ***@***.***> Sent: Tuesday, September 28, 2021 9:22 AM To: vaccineontology/VO ***@***.***> Cc: He, Oliver ***@***.***>; State change ***@***.***> Subject: Re: [vaccineontology/VO] VAC: Advax-CpG (Advax-2, Advax-SM) (#562) External Email - Use Caution Hi Oliver, that’s a good idea! There will be additional Advax-CpG records coming in soon (all using the same Advax (ie, Inulin) but CpGs with different sequences). Thanks! Wolfgang From: Yongqun Oliver He ***@***.***<mailto:***@***.***>> Sent: Friday, September 24, 2021 12:26 AM To: vaccineontology/VO ***@***.***<mailto:***@***.***>> Cc: Leitner, Wolfgang (NIH/NIAID) [E] ***@***.***<mailto:***@***.***>>; Author ***@***.***<mailto:***@***.***>> Subject: Re: [vaccineontology/VO] VAC: Advax-CpG (Advax-2, Advax-SM) (#562) I see. What about we keep the term Advax-CpG, and then add a new term "Advax-CpG55.2", which wil be a subclass term under Advax-CpG? — You are receiving this because you authored the thread. Reply to this email directly, view it on GitHub<#562 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AVAUNQV54ZP6T6R36CBFRSLUDP4T5ANCNFSM5DENIFZQ>. Triage notifications on the go with GitHub Mobile for iOS<https://apps.apple.com/app/apple-store/id1477376905?ct=notification-email&mt=8&pt=524675> or Android<https://play.google.com/store/apps/details?id=com.github.android&referrer=utm_campaign%3Dnotification-email%26utm_medium%3Demail%26utm_source%3Dgithub>. — You are receiving this because you modified the open/close state. Reply to this email directly, view it on GitHub<#562 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/ABD22Q5DZMFQZ2AUWZX7ZWLUEG6PNANCNFSM5DENIFZQ>. Triage notifications on the go with GitHub Mobile for iOS<https://apps.apple.com/app/apple-store/id1477376905?ct=notification-email&mt=8&pt=524675> or Android<https://play.google.com/store/apps/details?id=com.github.android&referrer=utm_campaign%3Dnotification-email%26utm_medium%3Demail%26utm_source%3Dgithub>. ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues

[yongqunh]

In the current VO version, Advax-CpG55.2 has the VO ID: VO_0005324.
http://purl.obolibrary.org/obo/VO_0005324
Advax-CpG, the higher "parent" level term, has the VO ID: VO_0005357.
http://purl.obolibrary.org/obo/VO_0005357

[yongqunh]

I checked Ontobee and found the VO vaccine adjuvant terms are loaded well. So I am going to close this issue.