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Trend Micro Antivirus blocks use of RunOnce #5482
This does not happen if you are using a Standard BootstrapperApplication:
Also if you are signing the bundle engine and the bundle file using msbuild this error does not occur:
Trend Micro logs the error when the custom bootstrapper application tries to write the RunOnce entry into the HKCU.
Currently I do not know why this error occurs and how to prevent it.