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Simulation of Nanopore Sequencing Signals Based on BiGRU

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NanosigSim

Simulation of Nanopore Sequencing Signals Based on BiGRU

Overview

Oxford Nanopore sequencing is an important sequencing technology, which reads the nucleotide sequence by detecting the electrical current signal changes when DNA molecule is forced to pass through a biological nanopore. The research on signal simulation of nanopore sequencing is highly desirable for method developments of nanopore sequencing applications. To improve the simulation accuracy, we propose a novel signal simulation method based on Bi-directional Gated Recurrent Units (BiGRU). We named the proposed method NanosigSim.

Download the NanosigSim package

git clone https://github.com/zpllx/NanosigSim.git
cd NanosigSim

Real Raw Signal VS Simulated Signal

Real Raw Signal

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Simulated Signal

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Simulation of Nanopore Sequencing Signals Based on BiGRU

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