A curated index of the best learning resources on CRISPR & gene editing.
If you’re completely new to these ideas, start with Start Here. This should tell you everything you’d ever need to know about CRISPR; but if you’re still curious, explore everything else below. Resources marked with ❗️ are difficult, and those with 🌟 are our favorite.
- Genetic Engineering Will Change Everything Forever – CRISPR
- How CRISPR lets us edit our DNA by Jennifer Doudna.
- A simple guide to CRISPR, one of the biggest science stories by VOX.
- Feng Zhang — One of the discoverers of CRISPR.
- Jennifer Doudna — One of the discoverers of CRISPR.
- Craig Venter — President of the J. Craig Venter Institute.
- Genome Editing Glossary by NEB.
- CRISPR Glossary by Addgene.
- CRISPR Gene Editing by Cancer Research.
- CRISPR/Cas9 Guide by addgene.
- Genetic Engineering Will Change Everything Forever – CRISPR by Kurzgesagt. ️🌟
- Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR by WIRED.
- How CRISPR lets us edit our DNA by Jennifer Doudna. ️🌟
- What you need to know about CRISPR by Ellen Jorgensen.
- What is CRISPR by Bozeman Science.
- The Dangers of CRISPR, Designer Babies, and Artificial Genetic Mutation by Richard Dawkins.
- What the CRISPR Embryo Editing Study Really Taught Us
- Are GMOs Good or Bad? Genetic Engineering & Our Food by Kurzgesagt.
- The $140 Mail-Order CRISPR Kit: Is Unregulated Biohacking the Future of Science?
- CRISPR-Cas9 (“Mr. Sandman” Parody)
- CRISPR: Gene editing and beyond by Nature Video.
- The Gene Hackers by the New Yorker ️🌟
- CRISPR: A game-changing genetic engineering technique by Harvard.
- A Powerful New Way to Edit DNA by The New York Times.
- Crispr Fans Dream of a Populist Future for Gene Editing by WIRED.
- A simple guide to CRISPR, one of the biggest science stories by VOX.
- An Astonishing Video Shows CRISPR Editing DNA in Real Time by the Atlantic.
- Engineering the Perfect Baby by MIT Technology Review.
- CRISPR/Cas9 and Targeted Genome Editing: A New Era in Molecular Biology by NEB.
- CRISPR: gene editing is just the beginning by Nature.
- Inside the summit on human gene editing: A reporter’s notebook by Science.
- Expanding the Biologist’s Toolkit with CRISPR-Cas9 by Jennifer A. Doudna and Samuel H. Sternberg
- CRISPR/Cas9 for genome editing: progress, implications and challenges by Feng Zhang.
- The new frontier of genome engineering with CRISPR-Cas9 by Science. 🌟
- Development and Applications of CRISPR-Cas9 for Genome Engineering by Patrick D. Hsu, Eric S. Lander, and Feng Zhang.
- Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9 by Rajat M. Gupta and Kiran Musunuru. ❗️
- The Genesis Engine by WIRED. 🌟
- CRISPR Timeline by Broad Institute.
- Cracking the Code: Jennifer Doudna and Her Amazing Molecular Scissors
- The Heroes of CRISPR by Eric S. Lander.
- Crispr’s Next Big Debate: How Messy Is Too Messy? by WIRED.
- Chinese Scientists Edit Genes of Human Embryos, Raising Concerns by The New York Times.
- Scientists make first ever attempt at gene editing inside the body by Associated Press.
- Welcome to the CRISPR zoo by Nature.
- Scientists Can Now Repaint Butterfly Wings by The Atlantic.
- The First Man to Have His Genes Edited Inside His Body by The Atlantic.
- Genetically Engineering Pigs to Grow Organs for People by The Atlantic.
- Q&A;: How gene editing could be the beginning of the end for disease by World Economic Forum.
- A New Drug Uses CRISPR to Fight Antibiotic-Resistant Bacteria by Futurism.
- Realizing the potential of CRISPR by Mckinsey & Company.
- Governance: Learn from DIY biologists by Nature.
- Perspective: Embryo editing needs scrutiny by Jennifer Doudna.
- Everything you need to know about gene editing by World Economic Forum.
- Genome Editing Using CRISPR-Cas Systems: Development and Prospects by Feng Zhang.
- CRISPR Biology and the New Era of Genome Engineering by Jennifer Doudna.
- The Gene: An Intimate History by Siddhartha Mukherjee.
- A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna and Samuel H. Sternberg.
- Introduction to Genomic Technologies by Johns Hopkins University
- Genomics: Decoding the Universal Language of Life by University of Illinois at Urbana-Champaign.
- Engineering Life: Synbio, Bioethics & Public Policy by Johns Hopkins University. ❗️
- Genomic and Precision Medicine by University of California, San Francisco. ❗ 🌟
- Genome Engineering Worshop at Cambridge, MA
- CRISPR Meetups
- Antibodies Part 1: CRISPR” by Radiolab.
- Update: CRISPR by Radiolab.
- Donation and Mutation by Radiolab.
- Crazy for CRISPR by Naked Genetics.
- Understanding CRISPR, the Sci-Fi-Esque Gene by The Leonard Lopate Show.
- The CRISPR Breakthrough by Future Tense.
- CRISPR and Cas-9 – how gene editing may one day lead to a cure for cancer by On the Map, Off the Radar.
- Paul Dabrowski – The CRISPR Revolution by Flux.
- Humanity 2.0 A Conversation with Jennifer A. Doudna by Sam Harris.
- Ishino, Y., H. Shinagawa, K. Makino, M. Amemura, and A. Nakata. "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product.” Journal of Bacteriology 169, no. 12 (1987): 5429-433. doi:10.1128/jb.169.12.5429-5433.1987. ❗️
- Barrangou, R., C. Fremaux, H. Deveau, M. Richards, P. Boyaval, S. Moineau, D. A. Romero, and P. Horvath. "CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes.” Science315, no. 5819 (2007): 1709-712. doi:10.1126/science.1138140. ❗️
- Marraffini, L. A., and E. J. Sontheimer. "CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA.” Science 322, no. 5909 (2008): 1843-845. doi:10.1126/science.1165771. ❗️
- Jinek, M., K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna, and E. Charpentier. "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.” Science 337, no. 6096 (2012): 816-21. doi:10.1126/science.1225829. ❗️
- Wang, Haoyi, Hui Yang, Chikdu S. Shivalila, Meelad M. Dawlaty, Albert W. Cheng, Feng Zhang, and Rudolf Jaenisch. "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering." Cell 153, no. 4 (2013): 910-18. doi:10.1016/j.cell.2013.04.025. ❗️
- Xie, Fei, Lin Ye, Judy C. Chang, Ashley I. Beyer, Jiaming Wang, Marcus O. Muench, and Yuet Wai Kan. "Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 andpiggyBac.” Genome Research 24, no. 9 (2014): 1526-533. doi:10.1101/gr.173427.114. ❗️
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. ❗️
- Platt, RJ., Chen, S., Zhou, Y., Yim, MJ., Swiech, L., Kempton, HR., Dahlman, JE., Parnas, O., Eisenhaure, TM., Jovanovic, M., Graham, DB., Jhunjhunwala, S., Heidenreich, M., Xavier, RJ., Langer, R., Anderson, DG., Hacohen, N., Regev, A., Feng, G., Sharp, PA., Zhang, F. “CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.” Cell Sep 24. pii: S0092-8674(14)01163-5. (2014). ❗️