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29045825.txt
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PMID- 29045825
OWN - NLM
STAT- In-Data-Review
LR - 20171223
IS - 1549-9642 (Electronic)
IS - 1549-9634 (Linking)
VI - 14
IP - 1
DP - 2018 Jan
TI - Cerenkov luminescence imaging on evaluation of early response to chemotherapy of
drug-resistant gastric cancer.
PG - 205-213
LID - S1549-9634(17)30180-6 [pii]
LID - 10.1016/j.nano.2017.10.001 [doi]
AB - Apoptosis imaging enables a timely and specific assessment of treatment response
in cancer patients. In this study, we applied a probe for positron emission
tomography (PET), which served as an optical biomaterial emitting Cerenkov
photons, to in vivo optical imaging of tumor apoptosis, in order to evaluate
early response to chemotherapy of drug-resistant gastric cancer.
(68)Ga-DOTA-Annexin V was prepared as the apoptosis targeting probe. Wild type
human gastric adenocarcinoma cell line SGC7901/WT and drug vincristine-resistant
variant SGC7901/VCR were used to establish normal and vincristine-resistant
xenografts to simulate treatment decision situation. Vincristine-resistance of
SGC7901/VCR and apoptosis-induction ability of vincristine and cisplatin were
verified. In vitro and in vivo CLI of apoptosis was performed. Stronger signals
of apoptosis of CLI correlated with confirmed higher levels of apoptosis and
subsequent changes in tumor sizes. Our study suggests that CLI is a promising
technique for in vivo imaging of apoptosis with radiopharmaceutical-labeled
biomaterials.
CI - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Liu, Muhan
AU - Liu M
AD - Engineering Research Center of Molecular and Neuro Imaging of Ministry of
Education & School of Life Science and Technology, Xidian University, Xi'an,
Shaanxi, China; CAS Key Laboratory of Molecular Imaging, Institute of Automation,
Beijing, China; Beijing Key Laboratory of Molecular Imaging, Beijing, China.
FAU - Zheng, Sheng
AU - Zheng S
AD - Department of Gastroenterology, General Hospital of Chinese People's Armed Police
Forces, Beijing, China.
FAU - Zhang, Xiaojun
AU - Zhang X
AD - Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Hongbo
AU - Guo H
AD - CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, China;
Beijing Key Laboratory of Molecular Imaging, Beijing, China; School of
Information Sciences and Technology, Northwest University, Xi'an, Shaanxi, China.
FAU - Shi, Xiaojing
AU - Shi X
AD - CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, China;
Beijing Key Laboratory of Molecular Imaging, Beijing, China; University of
Chinese Academy of Sciences, Beijing, China.
FAU - Kang, Xiaoyu
AU - Kang X
AD - State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases,
The Fourth Military Medical University, Xi'an, Shaanxi, China.
FAU - Qu, Yawei
AU - Qu Y
AD - Department of Gastroenterology, General Hospital of Chinese People's Armed Police
Forces, Beijing, China.
FAU - Hu, Zhenhua
AU - Hu Z
AD - CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, China;
Beijing Key Laboratory of Molecular Imaging, Beijing, China; University of
Chinese Academy of Sciences, Beijing, China; The State Key Laboratory of
Management and Control for Complex Systems, Beijing, China. Electronic address:
zhenhua.hu@ia.ac.cn.
FAU - Tian, Jie
AU - Tian J
AD - Engineering Research Center of Molecular and Neuro Imaging of Ministry of
Education & School of Life Science and Technology, Xidian University, Xi'an,
Shaanxi, China; CAS Key Laboratory of Molecular Imaging, Institute of Automation,
Beijing, China; Beijing Key Laboratory of Molecular Imaging, Beijing, China;
University of Chinese Academy of Sciences, Beijing, China; The State Key
Laboratory of Management and Control for Complex Systems, Beijing, China.
Electronic address: jie.tian@ia.ac.cn.
LA - eng
PT - Journal Article
DEP - 20171016
PL - United States
TA - Nanomedicine
JT - Nanomedicine : nanotechnology, biology, and medicine
JID - 101233142
OTO - NOTNLM
OT - Apoptosis
OT - Cerenkov luminescence imaging
OT - Cisplatin
OT - Gastric cancer
OT - Vincristine-resistance
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/09/09 00:00 [received]
PHST- 2017/10/02 00:00 [revised]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/10/19 06:00 [entrez]
AID - S1549-9634(17)30180-6 [pii]
AID - 10.1016/j.nano.2017.10.001 [doi]
PST - ppublish
SO - Nanomedicine. 2018 Jan;14(1):205-213. doi: 10.1016/j.nano.2017.10.001. Epub 2017
Oct 16.