Tests that no one passed

[dkoslicki]

We weren't able to investigate every one, but there appears to be quite a few tests that no ARAs pass, simply because that bioentity doesn't show up at all. Might indicate a different CURIE or bioentity should be chosen (eg. might be an sub-optimal test). Of course, mixed in with these are genuine underlying KP/filtering/ARA ranking issues, but nonetheless some are suspicious. Examples include:

Test 1 asset 13 Anakinra
Test 9 asset 262 AZD 335
Test 9 asset 264 Talcid (eg. according to NodeNorm, has no CHEBI or CHEMBL, just a UMLS CURIE)
Test 24, assets 390, 391, 392, 394, 395, 396, 397
Test 22 assets 368, 369, 370
Test 28, assets 493, 494, 496
Test 29, asset 503: is defined with "output_id": "CHEMBL.TARGET:CHEMBL204", and "output_name": "UNIPROTKB:P00734" which is a mixture of thrombin the gene/F2, and the output_id isn't even recognized by the node normalizer
Test 30, asset 599 the target CHEMBL.TARGET:CHEMBL2439 isn't even recognized by the node normalizer. Is CHEMBL.COMPOUND:CHEMBL2107858 intended?
Test 32 assets 637 and 638

[colleenXu]

I've looked at the runs over time, and I want to chime in...

Looking at 6/9- onward, I notice 25 assets that have consistently not been passed by any ARA:

• 14 interferon-beta 1a
• 262 AZD 3355
• 264 Talcid
• 306 interferon-beta 1b
• 355 Fosinopril
• 369 Diphenhydramine
• 370 Amiodarone
• 384 Beta-Blockers (Inhibitors)
• 389 Beta-2 Agonists (Activators)
• 390 azacitidine
• 391 decitabine
• 392 DNMT inhibitor
• 394 sodium butyrate
• 395 arginine butyrate
• 396 Butyrate Derivatives
• 397 hemin
• 493 pembrolizumab
• 496 trametinib
• 503 F2/thrombin
• 504 F2/thrombin
• 596 F2/thrombin
• 598 MPO/myeloperoxidase
• 618 omeprazole (started running 6/23)
• 637 CD36 (started running 6/23)
• 638 FABP5 (started running 6/23)

And 3 assets that some ARAs only started passing recently (I don't know how consistent this is yet):

• 13 anakinra (some now pass 7/27...)
• 383 ICI-118,551 (Unsecret now passes 7/13-)
• 597 MPO (Aragorn passed 7/27...)