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Nonspecific binding #456

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shbae1211 opened this issue Feb 5, 2020 · 1 comment
Open

Nonspecific binding #456

shbae1211 opened this issue Feb 5, 2020 · 1 comment

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@shbae1211
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@shbae1211 shbae1211 commented Feb 5, 2020

Hello, again..
I cannot find where to enter a nonspecific binding parameter (fu,mic,,,etc) for CLint and/or Ki.
Is this value automatically calculated by physicochem (Log P) and reflected model?

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/PK-Sim Feb 10, 2020
@tobiasK2001

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@tobiasK2001 tobiasK2001 commented Feb 11, 2020

Hi,
this value is calculated automatically here if you add a total liver CL based on microsome T1/2.

image
Please note, if you calculate Clint from hepatocytes, there is only a default value given. Ideally you have a measured fu in assay or you might think about using the calculated value from the microsomal assay or some literature value if available.

Hope this might help.

Best, Tobias

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