implementation of peripheral venous blood in Mobi for PD modeling

[CK-CHO]

Hello, i have a questions about implementation of peripheral venous plasma concentration.

I didn't find the peripheral venous plasma concentration in possible referenced objects in new parameters of spatial structures. Provided peripheral venous blood compartment were not clicked in the software.

How can i incorporating the plasma concentration-time profiles in the PD model?

When i used the table (multiple time discrete and piecewise constant numeric values) in specific time point nor the formula (an explicit formula) values, i confirmed that PD model is plausible. So, i want to incorporate the simulated profiles in the PD model, not the specific table for improvement of our model.

Please give me the opinion and help.

Thank you.

[PavelBal]

Hi,

the "PeripheralVenousBlood" is an observer. It is mixture of the concentrations in Muscle and Fat plasma. Observers cannot be used in equations.
Instead, you can use the "VenousBlood|Plasma" concentrations, which should be very close to the PeripheralVenousBlood unless your compound is extensively metabolized in muscle and/or fat.