Open Systems Pharmacology Suite Setup
Clone or download

This open source Systems Pharmacology project makes formerly commercial software tools PK-Sim® and MoBi® available as freeware under the GPLv2 License. All source code is public.

Latest suite release can be found here:

We invite everyone in the field of Systems Pharmacology, be it in academia, industry or regulatory bodies, to use the platform. Active participation of computer and modeling & simulation scientists in the further development of the modeling & simulation platform, the incorporated systems models, processes for their qualifaction and application etc. is encouraged and highly welcome! Please follow the community’s activities in this GitHub project.

Discussion forum for the Open Systems Pharmacology Project

Visit and subscribe to the Open Systems Pharmacology Project Forum to stay up-to-date with the community and receive updates on new software releases, models as well as discussions.

Open Systems Pharmacology Suite with PK-Sim® and MoBi® for Quantitative Systems Pharmacology

Unmatched Flexibility - Unlimited Transparency

platform concept

The Open Systems Pharmacology Suite contains different software tools and has been designed using a modular concept to allow efficient multi-scale modeling and simulation. The overall platform with its various software tools is implemented in a modular way as will be explained in more detail below. The central software tools PK-Sim® and MoBi® make use of building blocks as introduced here. While PK-Sim® is based on a whole-body concept, the focus of its counterpart, MoBi®, is at the molecular level. However, both tools extend to additional physiological scales as illustrated.

Code Status

Setup status PK-Sim status MoBi status Matlab status R status Installation Validator status

Software installation

How to install setups for the Open Systems Pharmacology Suite with PK-Sim® and MoBi®

  1. Download the Software Setup and install it on your computer. Make sure you are provided with administrator rights; these are required!
  2. Download PK-Sim Express Gene Expression Database and copy to a folder accessible for all users.
  3. Configure PK-Sim Gene Expression Database (for details view the Open Systems Pharmacology Suite manual chapter 10 „PK-Sim Options“)

System Requirements

Operating Systems

Windows 7®, Windows 8®, Windows 10®, Windows Server 2008 R2®, Windows Server 2012 R2®, Windows Server 2016®


Minimum: 1 GHz (the faster the better!)


Minimum: 2 GB RAM (3+ GB recommended)

Disk Space

Minimum: 2 GB

Optional Software

  • Matlab® (version 2013b or later - 32bit)
  • R® (versions 3.3 or later - 32bit)

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.


We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standards.

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