Define a model as ODEs

[amitvtaneja]

Hi Andy

Can a model be defined as a system of ODEs, since the example mentioned is for a one compartment model, analytical solution?
If so, could you please provide an example for a 2 cmgt model, oral absorption.

Thanks in advance

Amit Taneja

[andrewhooker]

Hi Amit,

Yes. Please see examples 1.c, 2.c, 8, 9 and 10 at https://github.com/andrewhooker/PopED/tree/master/inst/examples

Example 9 has what you are looking for.

Best regards,
Andy

[amitvtaneja]

Many Thanks Andy

Best regards

Amit

[liangqiongyue]

Hi andrewhooker
When I run the Example 9 (2 cmgt model, oral absorption) I run into some problems. The following error message appears when I run two lines of code:
###########
> system("R CMD SHLIB two_comp_oral_CL.c")
C:/PROGRA1/R/R-421.2/etc/x64/Makeconf:275: warning: overriding commands for target .m.o' C:/PROGRA~1/R/R-42~1.2/etc/x64/Makeconf:268: warning: ignoring old commands for target .m.o'
make: *** No rule to make target two_comp_oral_CL.o', needed by two_comp_oral_CL.dll'. Stop.
[1] 1
> dyn.load(paste("two_comp_oral_CL", .Platform$dynlib.ext, sep = ""))
Error in inDL(x, as.logical(local), as.logical(now), ...) :
unable to load shared object 'C:/Users/liangq3/AppData/Local/R/win-library/4.2/PopED/two_comp_oral_CL.dll':
LoadLibrary failure: The specified module could not be found.
###########
May I ask how to solve this problem? Thank you very much for your help!

[liangqiongyue]

> Hi andrewhooker When I run the Example 9 (2 cmgt model, oral absorption) I run into some problems. The following error message appears when I run two lines of code: ########### > system("R CMD SHLIB two_comp_oral_CL.c") C:/PROGRA1/R/R-421.2/etc/x64/Makeconf:275: warning: overriding commands for target .m.o' C:/PROGRA~1/R/R-42~1.2/etc/x64/Makeconf:268: warning: ignoring old commands for target .m.o' make: *** No rule to make target two_comp_oral_CL.o', needed by two_comp_oral_CL.dll'. Stop. [1] 1 > dyn.load(paste("two_comp_oral_CL", .Platform$dynlib.ext, sep = "")) Error in inDL(x, as.logical(local), as.logical(now), ...) : unable to load shared object 'C:/Users/liangq3/AppData/Local/R/win-library/4.2/PopED/two_comp_oral_CL.dll': LoadLibrary failure: The specified module could not be found. ########### May I ask how to solve this problem? Thank you very much for your help!

---

I found a solution to this problem, Just first installing Rtools42 first can be solved.
(https://cran.r-project.org/bin/windows/Rtools/rtools42/rtools.html)