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Filter the reference dictionary using lava filt. Just make sure to set GEN_FLT_DATA to 1 before generating the dictionaries.
Use a compact pileup table by setting PCOMPACT to 1.
The constants are all defined in include/lava.h. Let me know if you run into any issues. Also note that the RAM usage will be dependent on the size of your SNP list; that 5.2 GB number is based on the SNP list from the Affymetrix SNP array.
ON the main LAVA page, it says, "optionally using as little as 5.2 GB of RAM." How do I make it use less RAM?
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